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Small molecules

A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia

Carrie Selin, Maria S. Stietz, Jan E. Blanchard, Sebastian S. Gehrke, Sylvain Bernard, Dennis G. Hall, Eric D. Brown, Silvia T. Cardona

published 08 Jun 2015

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Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds

Ye Hu, Jürgen Bajorath

published 22 May 2015

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Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles

Ankit Srivastava, Prabha Arya, Surbhi Goel, Bishwajit Kundu, Prashant Mishra, Ashish Fnu

published 21 May 2015

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Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization

Valerie Berthelier, Jason Brett Harris, Kasey Noel Estenson, Jerome Baudry

published 11 May 2015

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Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor

Carolin Lübker, Roland Seifert

published 06 May 2015

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Free Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells

Krzysztof Bryniarski, Wlodzimierz Ptak, Emilia Martin, Katarzyna Nazimek, Marian Szczepanik, Marek Sanak, Philip W. Askenase

published 29 Apr 2015

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Structure- and Ligand-Based Virtual Screening Identifies New Scaffolds for Inhibitors of the Oncoprotein MDM2

Douglas R. Houston, Li-Hsuan Yen, Simon Pettit, Malcolm D. Walkinshaw

published 17 Apr 2015

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Sequence, Structure and Ligand Binding Evolution of Rhodopsin-Like G Protein-Coupled Receptors: A Crystal Structure-Based Phylogenetic Analysis

Steffen Wolf, Stefan Grünewald

published 16 Apr 2015

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High Serum β-Lactams Specific/Total IgE Ratio Is Associated with Immediate Reactions to β-Lactams Antibiotics

Alessandra Vultaggio, Gianni Virgili, Francesco Gaeta, Antonino Romano, Enrico Maggi, Andrea Matucci

published 16 Apr 2015

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Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines

Jutta Wanner, Darlene Romashko, Douglas S. Werner, Earl W. May, Yue Peng, Ryan Schulz, Kenneth W. Foreman, Suzanne Russo, Lee D. Arnold, Maneesh Pingle, Donald E. Bergstrom, Francis Barany, Stuart Thomson

published 15 Apr 2015

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Crystal Structure of the FLT3 Kinase Domain Bound to the Inhibitor Quizartinib (AC220)

Julie A. Zorn, Qi Wang, Eric Fujimura, Tiago Barros, John Kuriyan

published 02 Apr 2015

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Flavone Derivatives as Inhibitors of Insulin Amyloid-Like Fibril Formation

Ricardas Malisauskas, Akvile Botyriute, Jonathan G. Cannon, Vytautas Smirnovas

published 23 Mar 2015

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Quinoline Compound KM11073 Enhances BMP-2-Dependent Osteogenic Differentiation of C2C12 Cells via Activation of p38 Signaling and Exhibits In Vivo Bone Forming Activity

Seung-hwa Baek, Sik-Won Choi, Sang-Joon Park, Sang-Han Lee, Hang-Suk Chun, Seong Hwan Kim

published 19 Mar 2015

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