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Small molecules

Ready Access to Proquinazid Haptens via Cross-Coupling Chemistry for Antibody Generation and Immunoassay Development

Francesc A. Esteve-Turrillas, Josep V. Mercader, Javier Parra, Consuelo Agulló, Antonio Abad-Somovilla, Antonio Abad-Fuentes

published 27 Jul 2015

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Fully Flexible Docking of Medium Sized Ligand Libraries with RosettaLigand

Samuel DeLuca, Karen Khar, Jens Meiler

published 24 Jul 2015

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Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays

Jonathan A. Lee, Paul Shinn, Susan Jaken, Sarah Oliver, Francis S. Willard, Steven Heidler, Robert B. Peery, Jennifer Oler, Shaoyou Chu, Noel Southall, Thomas S. Dexheimer, Jeffrey Smallwood, Ruili Huang, Rajarshi Guha, Ajit Jadhav, Karen Cox, Christopher P. Austin, Anton Simeonov, G. Sitta Sittampalam, Saba Husain, Natalie Franklin, David J. Wild, Jeremy J. Yang, Jeffrey J. Sutherland, Craig J. Thomas

published 15 Jul 2015

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The Histone Methyltransferase Inhibitor A-366 Uncovers a Role for G9a/GLP in the Epigenetics of Leukemia

William N. Pappano, Jun Guo, Yupeng He, Debra Ferguson, Sujatha Jagadeeswaran, Donald J. Osterling, Wenqing Gao, Julie K. Spence, Marina Pliushchev, Ramzi F. Sweis, Fritz G. Buchanan, Michael R. Michaelides, Alexander R. Shoemaker, Chris Tse, Gary G. Chiang

published 06 Jul 2015

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Uncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor Selectivity

Abdelaziz Alsamarah, Alecander E. LaCuran, Peter Oelschlaeger, Jijun Hao, Yun Luo

published 02 Jul 2015

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Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency

Roger R. Beerli, Tamara Hell, Anna S. Merkel, Ulf Grawunder

published 01 Jul 2015

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Establishment of Magnetic Microparticles-Assisted Time-Resolved Fluoroimmunoassay for Determinating Biomarker Models in Human Serum

Zhi-Qi Ren, Tian-Cai Liu, Si-Hui Zhuang, Guan-Feng Lin, Jing-Yuan Hou, Ying-Song Wu

published 23 Jun 2015

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Murine Efficacy and Pharmacokinetic Evaluation of the Flaviviral NS5 Capping Enzyme 2-Thioxothiazolidin-4-One Inhibitor BG-323

Kristen M. Bullard, Rebekah C. Gullberg, Elnaz Soltani, J. Jordan Steel, Brian J. Geiss, Susan M. Keenan

published 15 Jun 2015

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Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays

Erkan Kiris, Jonathan E. Nuss, Stephanie M. Stanford, Laura M. Wanner, Lisa Cazares, Michael F. Maestre, Hao T. Du, Glenn Y. Gomba, James C. Burnett, Rick Gussio, Nunzio Bottini, Rekha G. Panchal, Christopher D. Kane, Lino Tessarollo, Sina Bavari

published 10 Jun 2015

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A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia

Carrie Selin, Maria S. Stietz, Jan E. Blanchard, Sebastian S. Gehrke, Sylvain Bernard, Dennis G. Hall, Eric D. Brown, Silvia T. Cardona

published 08 Jun 2015

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Quantifying the Tendency of Therapeutic Target Proteins to Bind Promiscuous or Selective Compounds

Ye Hu, Jürgen Bajorath

published 22 May 2015

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Gelsolin Amyloidogenesis Is Effectively Modulated by Curcumin and Emetine Conjugated PLGA Nanoparticles

Ankit Srivastava, Prabha Arya, Surbhi Goel, Bishwajit Kundu, Prashant Mishra, Ashish Fnu

published 21 May 2015

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Discovery of an Inhibitor of Z-Alpha1 Antitrypsin Polymerization

Valerie Berthelier, Jason Brett Harris, Kasey Noel Estenson, Jerome Baudry

published 11 May 2015

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