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Small molecules

Uncovering the molecular and physiological processes of anticancer leads binding human serum albumin: A physical insight into drug efficacy

Chuanbo Liu, Zuojia Liu, Jin Wang

published 20 Apr 2017

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Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors

Anneleen Van Hout, Thomas D’huys, Merel Oeyen, Dominique Schols, Tom Van Loy

published 14 Apr 2017

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The prognostic significance of DAPK1 in bladder cancer

Jian-Yun Xie, Peng-Chen Chen, Jia-Li Zhang, Ze-Shou Gao, Henrique Neves, Shu-Dong Zhang, Qing Wen, Wei-Dong Chen, Hang Fai Kwok, Yao Lin

published 07 Apr 2017

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Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics

Yu-Fen Chang, Connor N. Broyles, Frances A. Brook, Mark J. Davies, Cameron W. Turtle, Takeharu Nagai, Matthew J. Daniels

published 05 Apr 2017

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DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells

Kai Liu, Jian Mao, Lipu Song, Anran Fan, Sheng Zhang, Jianyu Wang, Nana Fan, Na Liu, Xiaoying Ye, Haifeng Fu, Zhongcheng Zhou, Yong Wang, Hong Wei, Zhonghua Liu, Ziyi Li, Liangxue Lai, Xumin Wang, Lin Liu

published 02 Mar 2017

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The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing

Qiyao Luo, Liang Zhao, Jianxing Hu, Hongwei Jin, Zhenming Liu, Liangren Zhang

published 14 Feb 2017

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Effective antibodies immobilization and functionalized nanoparticles in a quartz-crystal microbalance-based immunosensor for the detection of parathion

Bartolomeo Della Ventura, Marco Iannaccone, Riccardo Funari, Massimo Pica Ciamarra, Carlo Altucci, Rosanna Capparelli, Sante Roperto, Raffaele Velotta

published 09 Feb 2017

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Large-scale bioactivity analysis of the small-molecule assayed proteome

Tyler William H. Backman, Daniel S. Evans, Thomas Girke

published 08 Feb 2017

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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Adam Yasgar, Steven A. Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J. Maloney, Anton Simeonov, Natalia J. Martinez

published 27 Jan 2017

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Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation

Saptarshi Kar, David W. Smith, Bruce S. Gardiner, Alan J. Grodzinsky

published 15 Dec 2016

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A ^99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives

Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R. Genady, Salma A. Alkarmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J. Berti, John F. Valliant

published 09 Dec 2016

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Identification of a Novel Inhibitory Allosteric Site in p38α

Patricia Gomez-Gutierrez, Pedro M. Campos, Miguel Vega, Juan J. Perez

published 29 Nov 2016

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Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

W. Joon Chung, Jennifer L. Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M. Rowe, Zackery E. Plyler, Jeong S. Hong, Marina Mazur, Gary A. Piazza, Adam B. Keeton, E. Lucile White, Lynn Rasmussen, Allan M. Weissman, R. Aldrin Denny, Jeffrey L. Brodsky, Eric J. Sorscher

published 12 Oct 2016

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