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Small molecules

The scoring bias in reverse docking and the score normalization strategy to improve success rate of target fishing

Qiyao Luo, Liang Zhao, Jianxing Hu, Hongwei Jin, Zhenming Liu, Liangren Zhang

published 14 Feb 2017

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Effective antibodies immobilization and functionalized nanoparticles in a quartz-crystal microbalance-based immunosensor for the detection of parathion

Bartolomeo Della Ventura, Marco Iannaccone, Riccardo Funari, Massimo Pica Ciamarra, Carlo Altucci, Rosanna Capparelli, Sante Roperto, Raffaele Velotta

published 09 Feb 2017

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Large-scale bioactivity analysis of the small-molecule assayed proteome

Tyler William H. Backman, Daniel S. Evans, Thomas Girke

published 08 Feb 2017

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A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity

Adam Yasgar, Steven A. Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J. Maloney, Anton Simeonov, Natalia J. Martinez

published 27 Jan 2017

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Systems Based Study of the Therapeutic Potential of Small Charged Molecules for the Inhibition of IL-1 Mediated Cartilage Degradation

Saptarshi Kar, David W. Smith, Bruce S. Gardiner, Alan J. Grodzinsky

published 15 Dec 2016

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A ^99mTc-Labelled Tetrazine for Bioorthogonal Chemistry. Synthesis and Biodistribution Studies with Small Molecule trans-Cyclooctene Derivatives

Alyssa Vito, Hussain Alarabi, Shannon Czorny, Omid Beiraghi, Jeff Kent, Nancy Janzen, Afaf R. Genady, Salma A. Alkarmi, Stephanie Rathmann, Zoya Naperstkow, Megan Blacker, Lisset Llano, Paul J. Berti, John F. Valliant

published 09 Dec 2016

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Identification of a Novel Inhibitory Allosteric Site in p38α

Patricia Gomez-Gutierrez, Pedro M. Campos, Miguel Vega, Juan J. Perez

published 29 Nov 2016

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Increasing the Endoplasmic Reticulum Pool of the F508del Allele of the Cystic Fibrosis Transmembrane Conductance Regulator Leads to Greater Folding Correction by Small Molecule Therapeutics

W. Joon Chung, Jennifer L. Goeckeler-Fried, Viktoria Havasi, Annette Chiang, Steven M. Rowe, Zackery E. Plyler, Jeong S. Hong, Marina Mazur, Gary A. Piazza, Adam B. Keeton, E. Lucile White, Lynn Rasmussen, Allan M. Weissman, R. Aldrin Denny, Jeffrey L. Brodsky, Eric J. Sorscher

published 12 Oct 2016

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A High-Throughput Small Molecule Screen for C. elegans Linker Cell Death Inhibitors

Andrew R. Schwendeman, Shai Shaham

published 07 Oct 2016

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Computational Analysis and Predictive Cheminformatics Modeling of Small Molecule Inhibitors of Epigenetic Modifiers

Salma Jamal, Sonam Arora, Vinod Scaria

published 13 Sep 2016

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Small Molecule-Induced Complement Factor D (Adipsin) Promotes Lipid Accumulation and Adipocyte Differentiation

No-Joon Song, Suji Kim, Byung-Hyun Jang, Seo-Hyuk Chang, Ui Jeong Yun, Ki-Moon Park, Hironori Waki, Dean Y. Li, Peter Tontonoz, Kye Won Park

published 09 Sep 2016

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A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models

Natalia J. Martinez, Ganesha Rai, Adam Yasgar, Wendy A. Lea, Hongmao Sun, Yuhong Wang, Diane K. Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin Sagor, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J. Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J. Maloney, Anton Simeonov

published 29 Aug 2016

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MMpI: A WideRange of Available Compounds of Matrix Metalloproteinase Inhibitors

Charuvaka Muvva, Sanjukta Patra, Subramanian Venkatesan

published 10 Aug 2016

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