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Small interfering RNA

The FGFR inhibitor pemigatinib overcomes cancer drug resistance to KRAS G12C inhibitors in mesenchymal lung cancer

Angela Abdollahi, Margaret Favata, Michael Weber, Valerie Roman, Rodrigo Hess, Kayla Hammond, Matthew R. Farren, Mike Schaffer, Aidan Gilmartin, Hui Wang, Jonathan Rios-Doria, Alejandro Amador-Arjona

published 11 Aug 2025

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Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity

Okkeun Jung, Angelene Soto, Andrew L. Wolfe, Shahana S. Mahajan

published 08 Aug 2025

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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension

Lin Chen, Jiayao Chen, Jindong Wan, Muqing Shao, Caiyu Chen, Shuo Zheng, Fuwei Zhang, Jian Yang

published 05 Aug 2025

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Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation

Ayumi Goto, Michihiro Hashimoto, Sho Yokogawa, Yuzu Naruse, Hitoshi Yamashita

published 17 Jul 2025

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IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP

Shaojun Huang, Yao Cheng, Chengxin Zhang

published 14 Jul 2025

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MTMR7 regulates human spermatogonial stem cells proliferation and migration via targeting FLNB

Nianchao Zhou, Tiantian Wu, Yi Yu, Wenxin Gao, Bing Jiang, Haoyue Hu, Xiaoyan Huang, Cong Shen, Yibo Wu, Tingting Gao

published 10 Jul 2025

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Reciprocal effects of conditioned medium on gene and protein expression of limbal epithelial cells and limbal fibroblasts in congenital aniridia

Maximilian Berger, Nóra Szentmáry, Tim Berger, Julia Zimmermann, Simon Trusen, Berthold Seitz, Fabian N. Fries, Shweta Suiwal, Maryam Amini, Tanja Stachon

published 07 Jul 2025

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Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model

Francesca Sedda, Andrea Caddeo, Kavitha Sasidharan, Giovanni Perra, Rajesh Pal, Nicola Lai, Marta Anna Kowalik, Andrea Perra

published 03 Jul 2025

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The Hippo-YAP/β-catenin signaling axis coordinates odontogenic differentiation in dental pulp stem cells: Implications for dentin-pulp regeneration

Chang Chen, Qiqi Yun, Juanli Ran, Ziyao Zhou, Pengxiang Zhang, Rong Li

published 26 Jun 2025

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SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

Amol Tandon, Josh Lewis Stern

published 25 Jun 2025

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Prostaglandin E₂ dependent migration of human brain endothelial cells is mediated through Rho-Kinase-II

Gausal Azam Khan, Arjun Ghosh

published 23 Jun 2025

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AKR1C2 silencing promotes ferroptosis and inhibits proliferation, migration, and invasion in lung cancer cells

Yi Cui, Zhihui Liu

published 18 Jun 2025

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Effect of retinoic acid treatment on the retinoic acid signaling pathway in a human siRNA-based aniridia limbal epithelial cell model, in vitro

Shao-Lun Hsu, Tanja Stachon, Fabian N. Fries, Zhen Li, Shuailin Li, Shanhe Liu, Berthold Seitz, Swarnali Kundu, Maryam Amini, Shweta Suiwal, Nóra Szentmáry

published 18 Jun 2025

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