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Small interfering RNA

Cleavage of MALAT1 RNA by 14-nt sgRNA-guided tRNase Z^L

Masayuki Takahashi, Masayuki Nashimoto

published 18 Sep 2025

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C3AR1 may aggravate diabetic nephropathy by mediating oxidative stress via ITGB2 regulation in renal tubular epithelial cells

Alex Abura, Shan Gao

published 12 Sep 2025

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TGFBR1 gene silencing attenuates cardiomyopathy in the HFpEF mouse model

Xuanyang Shen, Weidong Li, Xiaolu Jiang, Hongfu Wen, Yuan Shen, Wen Zhang, Yongjian Peng, Guoping Kang

published 29 Aug 2025

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Piezo1 regulates autophagy in HT22 hippocampal neurons through the Ca²⁺/Calpain and Calcineurin/TFEB signaling pathways

Yatong Wu, Yan Lu, Hao Zhang, Suhe Dong, Ziqing Zhang, Sinian Wang, Fengsheng Li, Shimin Yin

published 26 Aug 2025

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Downregulation of NCOA4 expression indicates poor prognosis and promotes the progression of cholangiocarcinoma

Wenlong Shen, Yi Liu, Bing Dai, Changling Qin, Yongli Fu, Xi Li, Chi Liu

published 11 Aug 2025

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The FGFR inhibitor pemigatinib overcomes cancer drug resistance to KRAS G12C inhibitors in mesenchymal lung cancer

Angela Abdollahi, Margaret Favata, Michael Weber, Valerie Roman, Rodrigo Hess, Kayla Hammond, Matthew R. Farren, Mike Schaffer, Aidan Gilmartin, Hui Wang, Jonathan Rios-Doria, Alejandro Amador-Arjona

published 11 Aug 2025

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Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity

Okkeun Jung, Angelene Soto, Andrew L. Wolfe, Shahana S. Mahajan

published 08 Aug 2025

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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension

Lin Chen, Jiayao Chen, Jindong Wan, Muqing Shao, Caiyu Chen, Shuo Zheng, Fuwei Zhang, Jian Yang

published 05 Aug 2025

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Cellular repressor of E1A-stimulated genes 1 enhances skeletal muscle performance through the stimulation of muscle differentiation and Akt-mTOR signaling pathway activation

Ayumi Goto, Michihiro Hashimoto, Sho Yokogawa, Yuzu Naruse, Hitoshi Yamashita

published 17 Jul 2025

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IQGAP1 participates in endothelial cell apoptosis and regulates atherosclerosis by targeting YAP

Shaojun Huang, Yao Cheng, Chengxin Zhang

published 14 Jul 2025

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MTMR7 regulates human spermatogonial stem cells proliferation and migration via targeting FLNB

Nianchao Zhou, Tiantian Wu, Yi Yu, Wenxin Gao, Bing Jiang, Haoyue Hu, Xiaoyan Huang, Cong Shen, Yibo Wu, Tingting Gao

published 10 Jul 2025

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Reciprocal effects of conditioned medium on gene and protein expression of limbal epithelial cells and limbal fibroblasts in congenital aniridia

Maximilian Berger, Nóra Szentmáry, Tim Berger, Julia Zimmermann, Simon Trusen, Berthold Seitz, Fabian N. Fries, Shweta Suiwal, Maryam Amini, Tanja Stachon

published 07 Jul 2025

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Galectin-3 inhibition ameliorates hepatic steatosis in a multilineage 3D spheroid model

Francesca Sedda, Andrea Caddeo, Kavitha Sasidharan, Giovanni Perra, Rajesh Pal, Nicola Lai, Marta Anna Kowalik, Andrea Perra

published 03 Jul 2025

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