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Regulatory proteins

N-acetyl-L-leucine normalizes Transcription Factor EB activity by stereospecific bidirectional modulation in a HeLa cell model of Niemann-Pick disease type C

Lianne C. Davis, Wim Annaert, Rebecca Braine, Grant C. Churchill, Mallory Factor, Taylor Fields, Marc Patterson, Frances Platt, Dawn Shepherd, Michael Strupp, Antony Galione

published 17 Jul 2026

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TNF-α exacerbates postoperative plantar pain by regulating the expression of Nav1.8

Zilu Shang, Yu Li, Yun Zhang, Yajuan Gong

published 17 Jul 2026

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What topological and geometric structure do biological foundation models learn? Evidence from 141 hypotheses

Ihor Kendiukhov

published 17 Jul 2026

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Molecular mechanisms of autophagy disorder in diabetic neuropathy: Focusing on signaling pathways and regulation of lipid metabolism

Li Song, Lin Zhou, Weiwei Li

published 09 Jul 2026

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Identification of the oxidation stress-related gene signatures and functional verification of MINK1 in prostate cancer cells

Shuai Liang, Shuhua Zhou, Yangshuo Tang, Moyan Xiao, Ke Ye

published 08 Jul 2026

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The role of SALL1-MGST1 axis-mediated ferroptosis inhibition in chemoresistance of retinoblastoma

Zhuang Xiong, Weiwei Zhang, Xuebing Yu, Ruoshu Gu, Xue Zhang

published 06 Jul 2026

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Key targets and mechanisms by which gut microbiota-derived metabolites regulate Alzheimer’s disease through the immune - inflammatory pathway: Based on network pharmacology and molecular docking

Lei Miao, Fengwei Hou, Guanghong Li

published 06 Jul 2026

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Pachymic acid alleviates circadian rhythm disorders in high-fat diet-induced obesity mice via the sphingolipid pathway

Hong Yang, Yingxiu Mei, Jilan Chen, Jiawei Chen, Jiushuang Zhu, Lu Zhang, Yanju Gong, Gan Luo, Weijun Ding

published 01 Jul 2026

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Lactiplantibacillus plantarum GUANKE alleviates Zearalenone-induced intestinal dysfunction by modulating oxidative stress and inflammation

Qiaoning Chang, Yanchao Zhao, Han Li, Bin Zhang, Meidi Zhang, Pei Zhao, Jingmin He, Bugao Li, Ming D. Li

published 01 Jul 2026

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Neuroprotective mechanisms of Thai traditional brain tonic Phy-Blica-O against LPS-induced neuroinflammation: Inhibition of NF-κB in microglia and mice

Thammarat Kaewmanee, Palanivel Ganesan, Piyapong Choochana, Pinanong Na-Phatthalung, Samuel Abiodun Kehinde, Sasitorn Chusri

published 26 Jun 2026

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Isoginkgetin increases the expression of metal responsive transcripts but inhibits their translation

Claire Peneycad, Erin van Zyl, Abhinav Mohur, Bruce C. McKay

published 25 Jun 2026

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Tumor-associated M2 macrophages promote prostate cancer invasion through the M-CSF-PCLAF pathway

Yitian Ou, Chunwei Ye, Haiyang Jiang, Yong Zhu, Chengxing Xia, Delin Yang

published 22 Jun 2026

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IRX3 depletion promotes early cardiac commitment of hiPSC-Derived Cardiomyocytes

Agatha Ribeiro Kalthof, Nikolas Dresch Ferreira, Caio Mateus Silva, Iuri Cordeiro Valadão, Iguaracy Pinheiro de Sousa, Ester Riserio Matos Bertoldi, Vanessa Morais Lima, Lauro Thiago Turaca, Ana Beatriz Ruiz Afonso Barbosa, Miriam Helena Fonseca-Alaniz, Jean-Paul Concordet, Elida Adalgisa Neri, Jose E. Krieger

published 16 Jun 2026

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