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Randomized controlled trials

Adaptation and evaluation of a digital dialectical behaviour therapy for youth at clinical high risk for psychosis: A protocol for a feasibility randomized controlled trial

Thea Lynne Hedemann, Yun Lu, Sofia Campitelli, Lisa D. Hawke, Nelson Shen, Sarah Saperia, Brett D. M. Jones, Gillian Strudwick, Chelsey R. Wilks, Wei Wang, Marco Solmi, Michael Grossman, Muhammad Ishrat Husain, Nicole Kozloff, George Foussias, Muhammad Omair Husain

published 23 Dec 2025

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Effects of aquatic exercise on arterial stiffness and endothelial function in adults: A systematic review and meta-analyses

Emily Dunlap, Yanbing Zhou, Manny M.Y. Kwok, Billy C.L. So, Hirofumi Tanaka

published 12 Dec 2025

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Safety outcomes of statin vs non-statin lipid-lowering interventions in patients with prior statin-associated muscle symptoms: A systematic review and meta-analysis

Philipp Stefan Aebi, Fanny Villoz, Jonas Bührer, Christina Lyko, Nazanin Abolhassani, Cinzia Del Giovane, Baris Gencer, Nicolas Rodondi, Manuel R. Blum

published 11 Dec 2025

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The effects of high-frequency repetitive transcranial magnetic stimulation on negative symptoms in schizophrenia patients: A systemic review and meta-analysis

Boxing Wang, Xinyue Zhu, Ling Chen, Shuyun Liu, Chengshi Wang

published 11 Dec 2025

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Who gets included? A scoping review protocol of digital health interventions for older adults with heart failure through an equity lens

Kristina M. Kokorelias, Peter Hoang, Maurita T. Harris

published 04 Dec 2025

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Pharmacologic neuroprotective agents for the treatment of perinatal asphyxia in low-income and lower-middle-income countries: A systematic review and meta-analysis of randomised controlled trials

Victor Ayodeji Ayeni, Aisha Adam Abdullahi, Abdulmuminu Isah, Love Bukola Ayamolowo, Timothy Adeyemi, Motunrayo Adebukunola Oladimeji, Ufuoma Shalom Ahwinahwi, Vitalis Ikenna Chukwuike, Oluchukwu Perpetual Okeke, Olunike Rebecca Abodunrin, Folahanmi Tomiwa Akinsolu, Olajide Odunayo Sobande

published 04 Dec 2025

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Evaluation of umbilical cord blood serum eye drops for severe dry eye in two distinct populations—Sjögren’s syndrome and mustard gas–induced ocular injury: Protocol for a pilot randomized clinical trial

Seyed Hashem Daryabari, Hossein Aghamollaei, Seyyed Morteza Hosseini Imeni, Masoud Rostami

published 04 Dec 2025

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Comparison of Atezolizumab plus Aevacizumab and Atezolizumab plus Aabozantinib for advanced hepatocellular carcinoma: A cost-effectiveness analysis

Heng Xiang, Zhihua She, Liting Wang, Ye Peng, Lei Zhang, Chongqing Tan

published 03 Dec 2025

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Second-line treatment strategies of ulcerative colitis after conventional therapy failure: A systematic review and network meta-analysis of randomized controlled trials

Yanan Xu, Wenshuo Jiang, Meizhu Jiang, Bin Zhu, Jiping Huo, Mingfen Wu, Li Yang

published 01 Dec 2025

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Protocol for a randomized controlled trial of a combined motivational interviewing and behavioral couples therapy intervention to reduce intimate partner violence and alcohol use in south India

Meghna Achar, Megan Ramaiya, Krishnamachari Srinivasan, Maria L. Ekstrand, Elsa Heylen, Johnson Pradeep R, Miriam Hartmann, Nisha C. K, Matilda Pereira, Bibhav Acharya

published 01 Dec 2025

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Interventions to improve racial and ethnic equity in critical care: A scoping review

Shirley Ge, Hope Lappen, Luz Mercado, Kaylee Lamarche, Theodore J. Iwashyna, Catherine L. Hough, Virginia W. Chang, Adolfo Cuevas, Thomas S. Valley, Mari Armstrong-Hough

published 25 Nov 2025

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Safety and efficacy of radiotherapy combined with immunotherapy in limited-stage small cell lung cancer a single-arm meta-analysis and systematic review

Li Yu, Xinlin Yu, Cheng Ma, Xialin Zhang, Ran Cui

published 20 Nov 2025

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Effect of fascial closure using barbed sutures on incisional hernias in midline laparotomy for gynecological diseases: A multicenter randomized controlled trial (KGOG 4001)

Yong Jae Lee, Nam Kyeong Kim, Kidong Kim, Chel Hun Choi, Keun Ho Lee, Jong-Min Lee, Kwang Beom Lee, Dong Hoon Suh, Sunghoon Kim, Min Kyu Kim, Seok Ju Seong, Myong Cheol Lim

published 19 Nov 2025

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