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Randomized controlled trials

Who presents the greatest challenge in intellectual disability research- participants or health and research professionals?

Rosemary Kelly, Laurence Taggart, Vivien Coates, Maria Truesdale, Alison Dunkley, Michelle Hadjiconstantinou, Kamlesh Khunti, Nicola Mills

published 03 Nov 2025

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Feasibility, acceptability, and preliminary efficacy protocol of an intervention for caregivers of hospice patients living with dementia: A pilot randomized control trial

Ebtesam Tamer, Donald R. Hoover, Margaret V. McDonald, Kira G. Sheldon, Felix Vasquez, Maryam Gaibi, Elizabeth A. Luth

published 03 Nov 2025

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Myopia control efficacy of second-generation defocus incorporated multiple segments spectacle lenses on fast progressing myopes: Study protocol of a randomised controlled trial

Ying Hon, Rachel Ka Man Chun, Tsz Wing Leung, Hua Qi, Keigo Hasegawa, Ka Yan Leung, Chi Ho To, Carly Siu Yin Lam, Dennis Yan-Yin Tse

published 31 Oct 2025

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The effect of mindfulness-based stress reduction on presenteeism among ICU nurses: A cluster randomized controlled trial

Xiaoli Liu, Shu Luo, Xianxiu Wen, Xiahong Huang, Jijun Wu, Min Chen, Ping Jia

published 28 Oct 2025

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Effects of therapeutic climbing in healthcare and rehabilitation: A systematic review protocol

Bastien Delhoste, Fadl Moudni, Asiya Parvin Allaudeen, Bruno Chenuel, Edem Allado

published 24 Oct 2025

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Machine learning detects hidden treatment response patterns only in the presence of comprehensive clinical phenotyping

Stephen D. Auger, Gregory Scott

published 21 Oct 2025

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Comparing the effects of interactive and conventional video education on activation, treatment adherence, and weight changes in dialysis patients: A randomized clinical trial protocol

Sogand Sarmadi, Neda Sanaie, Akbar Zare-Kaseb

published 15 Oct 2025

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The impact of pulsatile vs. non-pulsatile perfusion in patients undergoing cardiopulmonary bypass: A comprehensive systematic review and meta-analysis of 33 randomized controlled trials

Mohamed R. Abdelraouf, Abdelrahman Mahmoud, Ahmed Mazen Amin, Hazem Mohamed Salamah, Hassan Alshaker, Hazem Rezq, Ali Ashraf Salah Ahmed, Mohamed Ahmed Ali, Abdallah Saeed, Majd M. AlBarakat, Dina Ayman, Salem Elshenawy, Abdul Rhman Hassan, Basant E. Katamesh, Basel Abdelazeem

published 14 Oct 2025

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Generalized estimating equations for modeling cluster randomized trial data on smoking cessation among tuberculosis patients

Vasantha Mahalingam, Ratnakar Singh, Ramesh Kumar Santhanakrishnan, Adhin Bhaskar, Ponnuraja Chinnaiyan

published 10 Oct 2025

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Pharmacoinvasive strategy versus fibrinolytic therapy alone in adults with ST-elevation myocardial infarction: A systematic review and meta-analysis

David R. Soriano-Moreno, Kimberly G. Tuco, Carolina J. Delgado Flores, Kevin Flores-Lovon, Fabricio Ccami-Bernal, Renatta Quijano-Escate, Luis Marcos López-Rojas, Sergio Goicochea-Lugo

published 09 Oct 2025

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Efficacy of prophylactic tranexamic acid among parturient at increased risk for postpartum hemorrhage undergoing cesarean delivery: A systematic review and meta-analyses of randomized controlled trials

Mohamed Aziz Daghmouri, Simon Crequit, Amelie Madeuf, Wael Chaabane, Ortéga Laurent, Patrick Lafforgue, Bechir Azzouzi, Ines Ouaz, Mohamed Ali Chaouch

published 09 Oct 2025

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Dipsticks and point-of-care Microscopy in Urinary Tract Infections in primary care: Results of the MicUTI pilot cluster randomised controlled trial

Peter K. Kurotschka, Martin J. Koch, Eva Bucher, Adolfo Figueiras, Jochen Gensichen, Alexander Hapfelmeier, Alastair D. Hay, Christian Kretzschmann, Oliver Kurzai, Thiên-Trí Lâm, Kathrin Lasher, Orietta Massidda, Linda Sanftenberg, Guido Schmiemann, Antonius Schneider, Anne Simmenroth, Stefanie Stark, Lisette Warkentin, Mark H. Ebell, Ildikó Gágyor, on behalf of the Bavarian Practice-Based Research Network (BayFoNet)

published 08 Oct 2025

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Systematic review protocol: The effects of theory-based interventions for self-help practices in the management of mild to moderate depression

Asma’ Khalil, Zahir Izuan Azhar, Norley Shuib, Philip Baker, Xin Wee Chen

published 07 Oct 2025

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