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Randomized controlled trials

Probiotics, synbiotics and berberine in Type 2 diabetes mellitus: A systematic review, meta-analysis, and molecular dynamics simulation study

Md. Shadin, Md. Shimul Bhuia, Mohammed Alfaifi, Faisal H. Altemani, Abdullah H. Altemani, Faisal Alsenani, Na’il Saleh, Muhammad Torequl Islam

published 29 May 2026

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Effectiveness of virtual clinical simulation in palliative care education for nursing students: Protocol of a randomized controlled trial

Zhixiang Sun, Pingpin Wen, Lu Zhang, Xiaoli Zhang, Xinyu Yang, Chunyan Liu, Jing Fu, Meifang Yang

published 28 May 2026

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Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial

Mandy H. M. Chu, Jacky K. M. Lai, Anna Lee, William K. K. Wu, Ziheng Huang, Henry M. K. Wong, Laptin Ho, Hao Su, Samantha S. M. Ho, Xinbo Xu, Warren Pavey, David J. R. Morgan, Matthew T. V. Chan, Kwok M. Ho

published 27 May 2026

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Restrictive versus liberal oxygenation targets in patients with acute heart failure and pulmonary congestion–A protocol for a Randomized Controlled Trial (The REDOX-AHF trial)

Ida Arentz Taraldsen, Anne Sophie Overgaard Olesen, Jasmin Dam Lukoschewitz, Ejvind Frausing Hansen, Olav Wendelboe Nielsen, Christian Hassager, Jens Jakob Thune, Maryam Noory, Arzu Karamat, Jens Dahlgaard Hove, Johannes Grand

published 22 May 2026

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Exercise-based cardiac rehabilitation and atherosclerotic plaque regression in ASCVD: Is exercise really a game-changer? A scoping review of controlled trials

Dwita Rian Desandri, Averina Octaxena Aslani, Faqrizal Ria Qhabibi, Dimitra Nikoletou

published 20 May 2026

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Spinal mechanisms and feasibility of Dry Needling versus Botulinum Toxin Type A in post-stroke lower limb spasticity: A proof-of-concept randomized clinical trial protocol (STROKE-POC)

Clara Pujol-Fuentes, Bart Eeckhaut, Samuel Fernández Carnero, Daniel Fernández Sanchís, Theodore Wein, Pablo Herrero, Wim Saeys, Mindy F. Levin

published 20 May 2026

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Maintaining function and participation through tailored 24-hour movement behaviours for people living with multiple long-term conditions and frailty (The PERSONAL-AGILITY study): Protocol for a randomised controlled feasibility trial

Martha Thomas, Louisa Y. Herring, Melanie J. Davies, Lucina Wilde, Vicky Hall, Laura J. Gray, Sharlene A. Greenwood, Michelle Hadjiconstantinou, Malak Hamza, Andrew Harris, Jemma Hawkins, Kamlesh Khunti, Matthew Maddocks, Atulkumar Rajpara, Alex Rowlands, Priscilla Sarkar, Avan A. Sayer, Sam Seidu, Tom Yates, Hannah M. L. Young

published 18 May 2026

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The impact of walking on creative thinking: A systematic review and meta-analysis

Alex Thabane, Vikram Arora, Joelle Boilard, Adam Sutoski, Sameer Parpia, Goran Calic, Jason W. Busse, Tyler McKechnie, Phillip Staibano, Mark Phillips, Roni Reiter-Palmon, Mohit Bhandari

published 13 May 2026

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Emotion-focused therapy and forgiveness in the older population: Protocol for a feasibility randomized controlled trial

Bernardo Corrêa d’Almeida, Carla Cunha

published 13 May 2026

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Nasal steroids, irrigation, oral antibiotics, and subgroup targeting for effective management of acute sinusitis (NOSES): Protocol for a comparative effectiveness randomized controlled trial

Daniel Merenstein, Nawar Shara, David P. Rabago, Derjung Mimi Tarn, Bruce Barrett, Alex H. Krist, Sebastian T. Tong, Aleksandra E. Zgierska, Tina P. Tan, Keisha Herbin Smith, Gabriela Villalobos, Charles R. Fencil, Kavya K. Sanghavi, Syed Junaid Imam, Stephen Fernandez, Mihriye Mete

published 06 May 2026

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Clinical trial participant information leaflets overstate the harms/risks of participation and understate the benefits

Rafaela Carapeto, Andrew Willis, Frances Shiely

published 05 May 2026

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Randomized controlled trial comparing AI-assisted digital and conventional orthodontics: Superior PAR reduction and occlusal outcomes

Xie Xiaoting, Nurul Azira Ismail, Mohammed Abdelfatah Alhoot, Liu Ying, Rabab Alayham Abbas Helmi, Qing Song, Li Ruiting

published 04 May 2026

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A secondary head-to-head comparison of low-intensity focused ultrasound and repetitive transcranial magnetic stimulation for motor recovery after stroke

Shuhong Zheng, Renxiu Bian, Haixin Song, Zhiping Liao, Ting Gao, Min Yan, Heqing Huang, Zuodong Lou, Fangchao Wu, Jianhua Li

published 24 Apr 2026

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