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Purkinje cells

Comparison of neonatal systemic and intracerebroventricular AAV9 gene therapy delivery demonstrating improved behavioral and phenotypic outcomes in a mouse model of Niemann-Pick disease, type C1

Benjamin E. Epstein, Gabrielle M. Soden, Arturo A. Incao, Avani Mylvara, Jonathan Flynn, Fatih Ozsolak, William J. Pavan

published 11 Mar 2026

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Restorative effects of Momordica charantia extract on cerebellar GFAP and NGF expression in pregnant diabetic rats and their offspring

Amoura M. Abou-El-Naga, Hend Abd EL-Halim Mansour, Mamdouh R. El-Sawi, Mai Alaa El-Dein, Yasmin M. Tag, Reham A. Ghanem, Manar A. Shawki

published 04 Apr 2025

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Identifying iNOS and glycogen as biomarkers for degenerated cerebellar purkinje cells in autism spectrum disorder: Protective effects of erythropoietin and zinc sulfate

Abdulaziz M. Al-Garni, Sara A. Hosny, Faris Almasabi, Ayed A. Shati, Norah M. Alzamil, Asmaa M. ShamsEldeen, Asmaa A. El-Shafei, Fahaid Al-Hashem, Hind Zafrah, Amro Maarouf, Bahjat Al-Ani, Ismaeel Bin-Jaliah, Samaa S. Kamar

published 13 Feb 2025

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Trazodone, dibenzoylmethane and tauroursodeoxycholic acid do not prevent motor dysfunction and neurodegeneration in Marinesco-Sjögren syndrome mice

Giada Lavigna, Anna Grasso, Chiara Pasini, Valentina Grande, Laura Mignogna, Elena Restelli, Antonio Masone, Claudia Fracasso, Jacopo Lucchetti, Marco Gobbi, Roberto Chiesa

published 13 Jan 2025

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Identification and characterization of two novel KCNH2 mutations contributing to long QT syndrome

Anthony Owusu-Mensah, Jacqueline Treat, Joyce Bernardi, Ryan Pfeiffer, Robert Goodrow, Bright Tsevi, Victoria Lam, Michel Audette, Jonathan M. Cordeiro, Makarand Deo

published 05 Jan 2024

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Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo

Collin M. MacLeod, Fawad A. K. Yousufzai, Liam T. Spencer, Sarah Kim, Lucianne A. Rivera-Rosario, Zerian D. Barrera, Lindsay Walsh, Claude Krummenacher, Benjamin Carone, Ileana Soto

published 30 Nov 2023

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GAD65 deficient mice are susceptible to ethanol-induced impairment of motor coordination and facilitation of cerebellar neuronal firing

Wataru Matsunaga, Toru Shinoe, Moritoshi Hirono

published 22 May 2023

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A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model

Shinichi Chisada, Kouki Ohtsuka, Masachika Fujiwara, Masao Yoshida, Satsuki Matsushima, Takashi Watanabe, Kanae Karita, Hiroaki Ohnishi

published 25 Apr 2023

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Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model

William Miller, Charles Lewis Humphrey Pruett, William Stone, Cindy Eide, Megan Riddle, Courtney Popp, Matthew Yousefzadeh, Christopher Lees, Davis Seelig, Elizabeth Thompson, Harry Orr, Laura Niedernhofer, Jakub Tolar

published 17 Oct 2022

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A 1 bp deletion in HACE1 causes ataxia in Norwegian elkhound, black

Kim K. L. Bellamy, Fredrik S. Skedsmo, Josefin Hultman, Ellen F. Arnet, Ole Albert Guttersrud, Hege Kippenes Skogmo, Stein Istre Thoresen, Arild Espenes, Karin Hultin Jäderlund, Frode Lingaas

published 21 Jan 2022

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A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells

Ayush Mandwal, Javier G. Orlandi, Christoph Simon, Jörn Davidsen

published 07 May 2021

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Kola nut from Cola nitida vent. Schott administered to pregnant rats induces histological alterations in pups’ cerebellum

Foluso A. Atiba, Amos A. Fatokun, Innocent O. Imosemi, Adefolarin O. Malomo

published 08 Mar 2021

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Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells

Friederike Auer, Eliana Franco Taveras, Uli Klein, Céline Kesenheimer, Dana Fleischhauer, Frank Möhrlen, Stephan Frings

published 02 Mar 2021

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