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Post-translational modification

Machine learning application to predict binding affinity between peptide containing non-canonical amino acids and HLA-A0201

Shan Jiang, Zhaoqian Su, Nathaniel Bloodworth, Yunchao Liu, Cristina E. Martina, David G. Harrison, Jens Meiler

published 27 Jun 2025

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Identification and mitigation of blood’s interference with the antimicrobial activity of AgNbO₃ particles

Cyrus Talebpour, Fereshteh Fani, Marc Ouellette, Marilynn Fairfax, Houshang Alamdari, Hossein Salimnia

published 24 Jun 2025

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Prostaglandin E₂ dependent migration of human brain endothelial cells is mediated through Rho-Kinase-II

Gausal Azam Khan, Arjun Ghosh

published 23 Jun 2025

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Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure

Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Yasumasa Mototani, Megumi Nariyama, Aiko Ito, Ichiro Matsuo, Yoshio Hayakawa, Akinaka Morii, Takao Mitsubayashi, Yasutake Saeki, Yoshihiro Ishikawa, Satoshi Okumura

published 17 Jun 2025

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JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events

Ilya Gurevic, Loic Meudec, Xavier Mariette, Gaetane Nocturne, Sara S. McCoy

published 16 Jun 2025

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Exploring the antioxidant, antiglycation, and anti-inflammatory potential of Oroxylum indicum stem bark extracts

Soraya Rodwattanagul, Pathomwat Wongrattanakamon, Siripat Chaichit, Chuda Chittasupho, Wutigri Nimlamool, Wim E. Hennink, Siriporn Okonogi

published 12 Jun 2025

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Cell death and iron deposition in the liver in two murine models of acute radiation syndrome

Dmitry T. Bradfield, John E. Slaven, W. Bradley Rittase, Milan Rusnak, Aviva J. Symes, Grace V. Brehm, Jeannie M. Muir, Sang-Ho Lee, Joseph A. Anderson, Regina M. Day

published 29 May 2025

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Epimedin C enhances mitochondrial energy supply by regulating the interaction between MIC25 and UBC in rodent model

Mi Huang, Lei Yu, Zhong Li, Ying Wang, Chunlin Yang

published 28 May 2025

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Anti-β₂GPI/β₂GPI complex promotes thrombosis by activating the P2Y₂/MAPKs pathway to increase human neutrophil peptides

Xin Guan, Wen Liu, Tianfeng Gao, Wenying Jin, Yueqiu Gao, Huiyuan Tan, Lujie Guo, Yanfen Zhang

published 22 May 2025

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Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity

Craig Eyster, Satoshi Matsuzaki, Atul Pranay, Jennifer R. Giorgione, Anna Faakye, Mostafa Ahmed, Kenneth M. Humphries

published 22 May 2025

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Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway

Yeonglim Kang, Jong-Chul Choi, Joong-Bok Lee, Seung-Yong Park, Changin Oh

published 20 May 2025

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Integrating in vitro and in silico approaches for exploring antidiabetic potential of dimethyl and thiomethyl indolinone derivatives

Kashif Ali, Ahmed A. Elhenawy, Waqas Alam, Khalaf F. Alsharif, Khalid J. Alzahrani, Haroon Khan, Long Chiau Ming, Rahul G. Ingle

published 16 May 2025

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Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

Taekyeol Lee, Dongsop Lee, Eunee Jung, Mikyung Son, Kyohwan Koo, Jaehoon Choi

published 15 May 2025

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