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Post-translational modification

Ganglioside GM3 prevents high fat diet-induced hepatosteatosis via attenuated insulin signaling pathway

Orie Tajima, Yuki Fujita, Yuhsuke Ohmi, Koichi Furukawa, Keiko Furukawa

published 24 Feb 2023

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α-Tubulin acetylation at lysine 40 regulates dendritic arborization and larval locomotion by promoting microtubule stability in Drosophila

Xiaoxiao Niu, Chuan-Xi Mao, Shan Wang, Xiongxiong Wang, Youyu Zhang, Juncheng Hu, Ran Bi, Zhihua Liu, Jin Shan

published 24 Feb 2023

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Novel Bruton’s tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis

Daichi Akasaka, Satoru Iguchi, Ryusuke Kaneko, Yohei Yoshiga, Daisuke Kajiwara, Yoshinori Nakachi, Naruto Noma, Kenji Tanaka, Atsushi Shimizu, Fumihito Hosoi

published 23 Feb 2023

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Merlin tumor suppressor function is regulated by PIP₂-mediated dimerization

Robert F. Hennigan, Craig S. Thomson, Kye Stachowski, Nicolas Nassar, Nancy Ratner

published 21 Feb 2023

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Metformin regulates myoblast differentiation through an AMPK-dependent mechanism

Eleonora Maniscalco, Giuliana Abbadessa, Magalì Giordano, Loredana Grasso, Paolo Borrione, Silvia Racca

published 10 Feb 2023

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Suppression of angiotensin converting enzyme 2, a host receptor for SARS-CoV-2 infection, using 5-aminolevulinic acid in vitro

Eriko Nara, Hung Wei Lai, Hideo Imazato, Masahiro Ishizuka, Motowo Nakajima, Shun-Ichiro Ogura

published 09 Feb 2023

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Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney

Geoff Harley, Marina Katerelos, Kurt Gleich, Mardiana Lee, Peter F. Mount, David A. Power

published 09 Feb 2023

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Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel

Mengyan Wei, Pu Wang, Xiufang Zhu, Masaki Morishima, Yangong Liu, Mingqi Zheng, Gang Liu, Hiroki Osanai, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono

published 02 Feb 2023

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The non-selective Rho-kinase inhibitors Y-27632 and Y-33075 decrease contraction but increase migration in murine and human hepatic stellate cells

Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein

published 31 Jan 2023

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Age-related changes in tau and autophagy in human brain in the absence of neurodegeneration

Shreyasi Chatterjee, Megan Sealey, Eva Ruiz, Chrysia M. Pegasiou, Keeley Brookes, Sam Green, Anna Crisford, Michael Duque-Vasquez, Emma Luckett, Rebecca Robertson, Philippa Richardson, Girish Vajramani, Paul Grundy, Diederik Bulters, Christopher Proud, Mariana Vargas-Caballero, Amritpal Mudher

published 26 Jan 2023

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The Q163C/Q309C mutant of α_MI-domain is an active variant suitable for NMR characterization

Hoa Nguyen, Tianwei Jing, Xu Wang

published 25 Jan 2023

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Stability analysis of a multiscale model of cell cycle dynamics coupled with quiescent and proliferating cell populations

Iqra Batool, Naim Bajcinca

published 20 Jan 2023

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Farnesol and phosphorylation of the transcriptional regulator Efg1 affect Candida albicans white-opaque switching rates

Lucas R. Brenes, Alexander D. Johnson, Matthew B. Lohse

published 20 Jan 2023

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