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Post-translational modification

Novel dual-pathogen multi-epitope mRNA vaccine development for Brucella melitensis and Mycobacterium tuberculosis in silico approach

Yuejie Zhu, Juan Shi, Quan Wang, Yun Zhu, Min Li, Tingting Tian, Huidong Shi, Kaiyu Shang, Zhengwei Yin, Fengbo Zhang

published 28 Oct 2024

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Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Sangavi Sivananthan, Varsha Bhakta, Negin Chaechi Tehrani, William P. Sheffield

published 23 Oct 2024

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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte, Pablo E. Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A. Offringa, Nazarius S. Lamango

published 22 Oct 2024

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Evidence for endogenous hydrogen peroxide production by E. coli fatty acyl-CoA dehydrogenase

Chaiyos Sirithanakorn, James A. Imlay

published 22 Oct 2024

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Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells

Kevin J. Kokesh, Niharika Bala, Yunus E. Dogan, Van-Anh L. Nguyen, Marcus Costa, Abdel Alli

published 16 Oct 2024

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The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

Florentin Pastor, Emilie Charles, Chiara Di Vona, Maëlys Chapelle, Michel Rivoire, Guillaume Passot, Benoit Chabot, Susana de la Luna, Julie Lucifora, David Durantel, Anna Salvetti

published 15 Oct 2024

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Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Kai Liu, Jing An, Jing Zhang, Jihu Zhao, Peng Sun, Zhaohui He

published 09 Oct 2024

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Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway

Shuchang Bao, Songzhe Li, Yang Sun

published 09 Oct 2024

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Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling

Natalia G. Armando, Paula A. dos Santos Claro, Mariana Fuertes, Eduardo Arzt, Susana Silberstein

published 02 Oct 2024

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Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

Juan Andrés Imelio, Felipe Trajtenberg, Sonia Mondino, Leticia Zarantonelli, Iakov Vitrenko, Laure Lemée, Thomas Cokelaer, Mathieu Picardeau, Alejandro Buschiazzo

published 26 Sep 2024

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Transcriptomic analysis reveals effects of fertilization towards growth and quality of Fritillariae thunbergii bulbus

Luman Huang, Shuang Liang, Lei Luo, Mengmin Wu, Hongwei Fu, Zhuoheng Zhong

published 20 Sep 2024

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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Kelly Lim, Winnie L. Kan, Pramod C. Nair, Monika Kutyna, Angel F. Lopez, Timothy Hercus, David M. Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

published 19 Sep 2024

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Glutathione transferase P1 is modified by palmitate

Vanessa Marensi, Megan C. Yap, Yuhuan Ji, Cheng Lin, Luc G. Berthiaume, Elaine M. Leslie

published 13 Sep 2024

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