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Post-translational modification

Ca²⁺-PP2B-PSD-95 axis: A novel regulatory mechanism of the phosphorylation state of Serine 295 of PSD-95

Takahiko Chimura, Toshiya Manabe

Dolichol kinases from yeast, nematode and human can replace each other and exchange their domains creating active chimeric enzymes in yeast

Danguole Ziogiene, Andrius Burdulis, [ ... ], Alma Gedvilaite

SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau

Motoki Imai, Fumitaka Kawakami, [ ... ], Makoto Kubo

Novel dual-pathogen multi-epitope mRNA vaccine development for Brucella melitensis and Mycobacterium tuberculosis in silico approach

Yuejie Zhu, Juan Shi, [ ... ], Fengbo Zhang

Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Sangavi Sivananthan, Varsha Bhakta, Negin Chaechi Tehrani, William P. Sheffield

Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, [ ... ], Nazarius S. Lamango

Evidence for endogenous hydrogen peroxide production by E. coli fatty acyl-CoA dehydrogenase

Chaiyos Sirithanakorn, James A. Imlay

Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells

Kevin J. Kokesh, Niharika Bala, [ ... ], Abdel Alli

The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

Florentin Pastor, Emilie Charles, [ ... ], Anna Salvetti

Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Kai Liu, Jing An, [ ... ], Zhaohui He

Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway

Shuchang Bao, Songzhe Li, Yang Sun

Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling

Natalia G. Armando, Paula A. dos Santos Claro, [ ... ], Susana Silberstein

Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

Juan Andrés Imelio, Felipe Trajtenberg, [ ... ], Alejandro Buschiazzo

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