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Post-translational modification

Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling

Natalia G. Armando, Paula A. dos Santos Claro, Mariana Fuertes, Eduardo Arzt, Susana Silberstein

published 02 Oct 2024

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Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

Juan Andrés Imelio, Felipe Trajtenberg, Sonia Mondino, Leticia Zarantonelli, Iakov Vitrenko, Laure Lemée, Thomas Cokelaer, Mathieu Picardeau, Alejandro Buschiazzo

published 26 Sep 2024

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Transcriptomic analysis reveals effects of fertilization towards growth and quality of Fritillariae thunbergii bulbus

Luman Huang, Shuang Liang, Lei Luo, Mengmin Wu, Hongwei Fu, Zhuoheng Zhong

published 20 Sep 2024

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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Kelly Lim, Winnie L. Kan, Pramod C. Nair, Monika Kutyna, Angel F. Lopez, Timothy Hercus, David M. Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

published 19 Sep 2024

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Glutathione transferase P1 is modified by palmitate

Vanessa Marensi, Megan C. Yap, Yuhuan Ji, Cheng Lin, Luc G. Berthiaume, Elaine M. Leslie

published 13 Sep 2024

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Multivalency drives interactions of alpha-synuclein fibrils with tau

Jennifer Ramirez, Ibrahim G. Saleh, Evan S. K. Yanagawa, Marie Shimogawa, Emily Brackhahn, E. James Petersson, Elizabeth Rhoades

published 10 Sep 2024

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Strategies found not to be suitable for stabilizing high steroid hydroxylation activities of CYP450 BM3-based whole-cell biocatalysts

Carolin Bertelmann, Bruno Bühler

published 06 Sep 2024

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Development of innovative multi-epitope mRNA vaccine against central nervous system tuberculosis using in silico approaches

Huidong Shi, Yuejie Zhu, Kaiyu Shang, Tingting Tian, Zhengwei Yin, Juan Shi, Yueyue He, Jianbing Ding, Quan Wang, Fengbo Zhang

published 06 Sep 2024

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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation

Santiago Sanchez, Aaron K. McDowell-Sanchez, Sharaz B. Al-Meerani, Juan D. Cala-Garcia, Alan R. Waich Cohen, Scott A. Ochsner, Neil J. McKenna, Lindsay J. Celada, Minghua Wu, Shervin Assassi, Ivan O. Rosas, Konstantin Tsoyi

published 06 Sep 2024

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Feasibility of the inhibitor development for cancer: A systematic approach for drug design

Yu Jiang, Ling Liu, Yichao Geng, Qingsong Li, Daxian Luo, Li Liang, Wei Liu, Weiwei Ouyang, Jianping Hu

published 22 Aug 2024

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KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats

Gagandeep Mann, Stephen Mora, Olasunkanmi A. John Adegoke

published 20 Aug 2024

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Remote liver ischemic preconditioning protects against renal ischemia/reperfusion injury via phosphorylation of extracellular signal-regulated kinases 1 and 2 in mice

Qifeng Wang, Junshen Xiao, Shichao Wei, Xi Yang, Jiaxue Li, Yunxia Zuo, Zhaoyang Hu

published 19 Aug 2024

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Atorvastatin inhibits Lipopolysaccharide (LPS)-induced vascular inflammation to protect endothelium by inducing Heme Oxygenase-1 (HO-1) expression

Jian Luo, Qian Zhu, Keming Huang, Xue Wen, Yongquan Peng, Gong Chen, Gang Wei

published 15 Aug 2024

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