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Post-translational modification

Proteomic and ubiquitinome analysis reveal that microgravity affects glucose metabolism of mouse hearts by remodeling non-degradative ubiquitination

Xin Zhang, Xuemei Zhou, Zhiwei Tu, Lihua Qiang, Zhe Lu, Yuping Xie, Cui Hua Liu, Lingqiang Zhang, Yesheng Fu

published 14 Nov 2024

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Palmitoyl-L-carnitine induces tau phosphorylation and mitochondrial dysfunction in neuronal cells

Gwangho Yoon, Min Kyoung Kam, Young Ho Koh, Chulman Jo

published 13 Nov 2024

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Ca²⁺-PP2B-PSD-95 axis: A novel regulatory mechanism of the phosphorylation state of Serine 295 of PSD-95

Takahiko Chimura, Toshiya Manabe

published 07 Nov 2024

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Dolichol kinases from yeast, nematode and human can replace each other and exchange their domains creating active chimeric enzymes in yeast

Danguole Ziogiene, Andrius Burdulis, Albertas Timinskas, Ruta Zinkeviciute, Emilija Vasiliunaite, Milda Norkiene, Alma Gedvilaite

published 07 Nov 2024

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SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau

Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kubo

published 30 Oct 2024

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Novel dual-pathogen multi-epitope mRNA vaccine development for Brucella melitensis and Mycobacterium tuberculosis in silico approach

Yuejie Zhu, Juan Shi, Quan Wang, Yun Zhu, Min Li, Tingting Tian, Huidong Shi, Kaiyu Shang, Zhengwei Yin, Fengbo Zhang

published 28 Oct 2024

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Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Sangavi Sivananthan, Varsha Bhakta, Negin Chaechi Tehrani, William P. Sheffield

published 23 Oct 2024

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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte, Pablo E. Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A. Offringa, Nazarius S. Lamango

published 22 Oct 2024

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Evidence for endogenous hydrogen peroxide production by E. coli fatty acyl-CoA dehydrogenase

Chaiyos Sirithanakorn, James A. Imlay

published 22 Oct 2024

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Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells

Kevin J. Kokesh, Niharika Bala, Yunus E. Dogan, Van-Anh L. Nguyen, Marcus Costa, Abdel Alli

published 16 Oct 2024

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The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

Florentin Pastor, Emilie Charles, Chiara Di Vona, Maëlys Chapelle, Michel Rivoire, Guillaume Passot, Benoit Chabot, Susana de la Luna, Julie Lucifora, David Durantel, Anna Salvetti

published 15 Oct 2024

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Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Kai Liu, Jing An, Jing Zhang, Jihu Zhao, Peng Sun, Zhaohui He

published 09 Oct 2024

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Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway

Shuchang Bao, Songzhe Li, Yang Sun

published 09 Oct 2024

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