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Post-translational modification

DJ-1 alleviates high glucose-induced podocyte injury via activating ERK1/2 signaling

Xiaochen Tian, Jing Li, Tao Han, Leisheng Zhang, Ping Lu, Yusheng Liu

published 17 Apr 2026

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SHPRH together with the Ube2D family of enzymes directly ubiquitinates PCNA at Lys164 in vitro

Xinyang Wang, Yixiong Hu, Yajiao Wen, Miaomiao Shen, Pu Chen, Song Xiang

published 16 Apr 2026

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Advanced machine learning-guided optimization platform for high-yield soluble expression of Pseudomonas aeruginosa exotoxin A in engineered Escherichia coli strains

Shah Faisal Mohammad, Fawad Ali, Mamirkulova Shynara

published 10 Apr 2026

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Human resistin is critical to activation of the NLRP3 inflammasome in macrophages

Udeshika Kariyawasam, Winson Lam, John Skinner, Rituparna Chakrabarti, Andrea Cox, Paul M. Hassoun, Qing Lin, Roger A. Johns

published 10 Apr 2026

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Identification of neuronatin as a SERCA2b regulin-like protein and assessment of its aggregation propensity via coarse grained simulations

Omar Ben Mariem, Lara Coppi, Emma De Fabiani, Ivano Eberini, Maurizio Crestani

published 09 Apr 2026

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Proteome-based investigation of O-GlcNAcylation in a C. elegans model of ageing and Alzheimer’s disease: Functional support for earlier hypothesis-generating findings

Fernando Garcia Olivera

published 30 Mar 2026

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Plasma heme pool compartmentalization is linked to pathophysiology in Sickle Cell Disease

Moritz Saxenhofer, Daniel Couto, Sandra Mena Perez, Marlies Illi, Justine Brodard, Linet Njue, Ioannis Chanias, Cesare Medri, Gerasimos Tsilimidos, Nicole Hadorn, Christelle Chirlias, Ana-Patricia Batista Mesquita, Lucas Veuthey, Anna Schnell, Stefanie Graeter, Gregory J. Kato, Jacqueline Adam, Ramona Merki, Emmanuel Levrat, Kaveh Samii, Mila Keiser, Kathrin Susann Bieri, Alan G. Haynes, Anne Angelillo-Scherrer, Lorenzo Alberio, Francesco Grandoni, Mathilde Gavillet, Thomas Gentinetta, Alicia Rovó, Alexander Schaub

published 26 Mar 2026

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Age-associated accumulation of carbamylation-derived products in tissues is independent from the myeloperoxidase pathway in mice

Christine Pietrement, Anaïs Okwieka, Lucile Cadoret, Manon Doué, Philippe Gillery, Stéphane Jaisson

published 16 Mar 2026

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Computational modelling of the equine arteritis virus GP5/M Dimer: Implications for immune evasion and virulence

Michael Veit, Anna Karolina Matczuk

published 10 Mar 2026

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Myc and Skp2 overexpression promotes p27 ubiquitination and degradation in Ewing Sarcoma

Yuta Kubota, Masanori Kawano, Ichiro Itonaga, Nobuhiro Kaku, Kazuhiro Tanaka

published 09 Mar 2026

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Phosphorylations of serines 21/9 in glycogen synthase kinase 3α/β are dispensable for ^V600EBRAF-driven premalignant tumour development in the mouse intestine

Pooyeh Farahmand, Paulina Rzasa, Caleb Green, Fiona Hey, Susan Giblett, Hong Jin, Kevin West, Nicolas B. Sylvius, Catrin A. Pritchard, Alessandro Rufini

published 06 Mar 2026

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Characterization of the TREM-1 signaling landscape in human neutrophils

Frederic Ries, Matthias Klein, Nora Rogmann, Sophie Többen, Federico Marini, Florian Heidel, Markus P. Radsak

published 05 Mar 2026

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Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype

Xuerao Ning, Thảo Thi Thanh Nguyễn, Takao Morinaga, Yuji Tada, Hideaki Shimada, Kenzo Hiroshima, Naoto Yamaguchi, Masatoshi Tagawa

published 23 Feb 2026

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