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Phosphorylation

SARS-CoV-2 propagation to the TPH2-positive neurons in the ventral tegmental area induces cell death via GSK3β-dependent accumulation of phosphorylated tau

Motoki Imai, Fumitaka Kawakami, Takayuki Uematsu, Toshihide Matsumoto, Rei Kawashima, Yoshifumi Kurosaki, Shun Tamaki, Shotaro Maehana, Takafumi Ichikawa, Hideaki Hanaki, Hidero Kitazato, Makoto Kubo

published 30 Oct 2024

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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte, Pablo E. Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A. Offringa, Nazarius S. Lamango

published 22 Oct 2024

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Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells

Kevin J. Kokesh, Niharika Bala, Yunus E. Dogan, Van-Anh L. Nguyen, Marcus Costa, Abdel Alli

published 16 Oct 2024

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The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

Florentin Pastor, Emilie Charles, Chiara Di Vona, Maëlys Chapelle, Michel Rivoire, Guillaume Passot, Benoit Chabot, Susana de la Luna, Julie Lucifora, David Durantel, Anna Salvetti

published 15 Oct 2024

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Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Kai Liu, Jing An, Jing Zhang, Jihu Zhao, Peng Sun, Zhaohui He

published 09 Oct 2024

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Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway

Shuchang Bao, Songzhe Li, Yang Sun

published 09 Oct 2024

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Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling

Natalia G. Armando, Paula A. dos Santos Claro, Mariana Fuertes, Eduardo Arzt, Susana Silberstein

published 02 Oct 2024

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Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

Juan Andrés Imelio, Felipe Trajtenberg, Sonia Mondino, Leticia Zarantonelli, Iakov Vitrenko, Laure Lemée, Thomas Cokelaer, Mathieu Picardeau, Alejandro Buschiazzo

published 26 Sep 2024

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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Kelly Lim, Winnie L. Kan, Pramod C. Nair, Monika Kutyna, Angel F. Lopez, Timothy Hercus, David M. Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

published 19 Sep 2024

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Multivalency drives interactions of alpha-synuclein fibrils with tau

Jennifer Ramirez, Ibrahim G. Saleh, Evan S. K. Yanagawa, Marie Shimogawa, Emily Brackhahn, E. James Petersson, Elizabeth Rhoades

published 10 Sep 2024

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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation

Santiago Sanchez, Aaron K. McDowell-Sanchez, Sharaz B. Al-Meerani, Juan D. Cala-Garcia, Alan R. Waich Cohen, Scott A. Ochsner, Neil J. McKenna, Lindsay J. Celada, Minghua Wu, Shervin Assassi, Ivan O. Rosas, Konstantin Tsoyi

published 06 Sep 2024

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Feasibility of the inhibitor development for cancer: A systematic approach for drug design

Yu Jiang, Ling Liu, Yichao Geng, Qingsong Li, Daxian Luo, Li Liang, Wei Liu, Weiwei Ouyang, Jianping Hu

published 22 Aug 2024

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KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats

Gagandeep Mann, Stephen Mora, Olasunkanmi A. John Adegoke

published 20 Aug 2024

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