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Phosphorylation

Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, [ ... ], Nazarius S. Lamango

Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells

Kevin J. Kokesh, Niharika Bala, [ ... ], Abdel Alli

The dual-specificity kinase DYRK1A interacts with the Hepatitis B virus genome and regulates the production of viral RNA

Florentin Pastor, Emilie Charles, [ ... ], Anna Salvetti

Network pharmacology combined with experimental validation show that apigenin as the active ingredient of Campsis grandiflora flower against Parkinson’s disease by inhibiting the PI3K/AKT/NF-κB pathway

Kai Liu, Jing An, [ ... ], Zhaohui He

Hederagenin regulates the migration and invasion of hepatocellular carcinoma cells through FOXO signaling pathway

Shuchang Bao, Songzhe Li, Yang Sun

Role of canonical and non-canonical cAMP sources in CRHR2α-dependent signaling

Natalia G. Armando, Paula A. dos Santos Claro, [ ... ], Susana Silberstein

Signal-sensing triggers the shutdown of HemKR, regulating heme and iron metabolism in the spirochete Leptospira biflexa

Juan Andrés Imelio, Felipe Trajtenberg, [ ... ], Alejandro Buschiazzo

CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Kelly Lim, Winnie L. Kan, [ ... ], Daniel Thomas

Multivalency drives interactions of alpha-synuclein fibrils with tau

Jennifer Ramirez, Ibrahim G. Saleh, [ ... ], Elizabeth Rhoades

PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation

Santiago Sanchez, Aaron K. McDowell-Sanchez, [ ... ], Konstantin Tsoyi

Feasibility of the inhibitor development for cancer: A systematic approach for drug design

Yu Jiang, Ling Liu, [ ... ], Jianping Hu

KIC (ketoisocaproic acid) and leucine have divergent effects on tissue insulin signaling but not on whole-body insulin sensitivity in rats

Gagandeep Mann, Stephen Mora, Olasunkanmi A. John Adegoke

Remote liver ischemic preconditioning protects against renal ischemia/reperfusion injury via phosphorylation of extracellular signal-regulated kinases 1 and 2 in mice

Qifeng Wang, Junshen Xiao, [ ... ], Zhaoyang Hu

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