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Phosphorylation

The antiadipogenic effect of the pentacyclic triterpenoid isoarborinol is mediated by LKB1-AMPK activation

Yesenia Arcos-Reyes, Gildardo Rivera, Laurence A. Marchat, Juan Salas-Benito, Gilberto Mandujano-Lázaro, Moisés Monzón-Gualito, Esther Ramírez-Moreno

published 03 Sep 2025

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Structural disorder and distinctive motifs in the C-terminal region of the MADS-domain transcription factors are conserved across diverse taxa

Erandi Ramírez-Aguirre, Teresa Beatriz Nava-Ramírez, Alejandra A. Covarrubias, Adriana Garay-Arroyo

published 22 Aug 2025

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Role of G-protein-coupled receptor kinase 4 on the dysfunction of renal Mas receptor in hypertension

Lin Chen, Jiayao Chen, Jindong Wan, Muqing Shao, Caiyu Chen, Shuo Zheng, Fuwei Zhang, Jian Yang

published 05 Aug 2025

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Protopanaxadiol stimulates glucose consumption by modulating the AMP-activated protein kinase pathway in myotubes, hepatoma cells, and adipocytes

Dahae Lee, Sang Hee Shim, Ki Sung Kang

published 29 Jul 2025

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Response Gene to Complement 32 promotes cell proliferation and tamoxifen resistance in breast cancer via elevated FoxM1 expression

Xinlei Li, Yan Liu, Zhiqian Wang, Xiaocui Bu, Yu Wang, Wei Zhang, Peng Zhao

published 28 Jul 2025

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Phosphatidylcholine suppresses inflammatory responses in LPS-stimulated MG6 microglial cells by inhibiting NF-κB/JNK/p38 MAPK signaling

Sachiko Mizuno, Yuki Kurobe-Takashima, Daisuke Kuriki, Kenta Susaki, Kurataka Otsuka, Tomoko Tsuchihashi, Keiko Abe, Shoko Kobayashi

published 28 Jul 2025

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Proteomic and phosphoproteomic analysis of rabies pathogenesis in the clinical canine brain and identification of a kinase inhibitor as a potential repurposed antiviral agent

Peerut Chienwichai, Kunjimas Ketsuwan, Boonlert Lumlertdacha, Chanon Fa-Ngoen, Punchaya Supasawat, Rojjanaporn Pulmanausahakul, Promsin Masrinoul, Tipparat Thiangtrongjit, Onrapak Reamtong

published 27 Jun 2025

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Prostaglandin E₂ dependent migration of human brain endothelial cells is mediated through Rho-Kinase-II

Gausal Azam Khan, Arjun Ghosh

published 23 Jun 2025

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Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure

Yoshiki Ohnuki, Kenji Suita, Misao Ishikawa, Yasumasa Mototani, Megumi Nariyama, Aiko Ito, Ichiro Matsuo, Yoshio Hayakawa, Akinaka Morii, Takao Mitsubayashi, Yasutake Saeki, Yoshihiro Ishikawa, Satoshi Okumura

published 17 Jun 2025

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JAK inhibitor withdrawal causes a transient pro-inflammatory cascade: A potential mechanism for major adverse cardiac events

Ilya Gurevic, Loic Meudec, Xavier Mariette, Gaetane Nocturne, Sara S. McCoy

published 16 Jun 2025

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Anti-β₂GPI/β₂GPI complex promotes thrombosis by activating the P2Y₂/MAPKs pathway to increase human neutrophil peptides

Xin Guan, Wen Liu, Tianfeng Gao, Wenying Jin, Yueqiu Gao, Huiyuan Tan, Lujie Guo, Yanfen Zhang

published 22 May 2025

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Mechanistic studies of PFKFB2 reveal a novel inhibitor of its kinase activity

Craig Eyster, Satoshi Matsuzaki, Atul Pranay, Jennifer R. Giorgione, Anna Faakye, Mostafa Ahmed, Kenneth M. Humphries

published 22 May 2025

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Rottlerin inhibits macropinocytosis of Porcine Reproductive and Respiratory Syndrome Virus through the PKCδ-Cofilin signaling pathway

Yeonglim Kang, Jong-Chul Choi, Joong-Bok Lee, Seung-Yong Park, Changin Oh

published 20 May 2025

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