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Phosphodiesterases

Unveiling of phosphodiesterase-5 hot residues binding to xanthine derivatives for erectile dysfunction therapy: A computational drug repurposing approach

Amin O. Elzupir, Sondos A. J. Almahmoud

published 13 Nov 2025

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Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes

Samuel Kasson, Nuwani Dharmapriya, In-Kwon Kim

published 30 Jun 2021

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High frequency of potential phosphodiesterase type 5 inhibitor drug interactions in males with HIV infection and erectile dysfunction

Jason M. Cota, Taylor M. Benavides, John D. Fields, Nathan Jansen, Anuradha Ganesan, Rhonda E. Colombo, Jason M. Blaylock, Ryan C. Maves, Brian K. Agan, Jason F. Okulicz

published 06 May 2021

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Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive bladder

Brian M. Balog, Abhilasha Tangada, Pooja Sheth, Qi-Xiang Song, Bruna M. Couri, Leah L. Porras, Gary G. Deng, Margot S. Damaser

published 28 Aug 2019

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Characterization of biochemical properties of an apurinic/apyrimidinic endonuclease from Helicobacter pylori

Aigerim Turgimbayeva, Sailau Abeldenov, Dmitry O. Zharkov, Alexander A. Ishchenko, Yerlan Ramankulov, Murat Saparbaev, Bekbolat Khassenov

published 15 Aug 2018

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Relative contributions of norspermidine synthesis and signaling pathways to the regulation of Vibrio cholerae biofilm formation

Caitlin K. Wotanis, William P. Brennan III, Anthony D. Angotti, Elizabeth A. Villa, Josiah P. Zayner, Alexandra N. Mozina, Alexandria C. Rutkovsky, Richard C. Sobe, Whitney G. Bond, Ece Karatan

published 18 Oct 2017

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The Characterization of Escherichia coli CpdB as a Recombinant Protein Reveals that, besides Having the Expected 3´-Nucleotidase and 2´,3´-Cyclic Mononucleotide Phosphodiesterase Activities, It Is Also Active as Cyclic Dinucleotide Phosphodiesterase

Iralis López-Villamizar, Alicia Cabezas, Rosa María Pinto, José Canales, João Meireles Ribeiro, José Carlos Cameselle, María Jesús Costas

published 13 Jun 2016

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Exposure to an Extremely-Low-Frequency Magnetic Field Stimulates Adrenal Steroidogenesis via Inhibition of Phosphodiesterase Activity in a Mouse Adrenal Cell Line

Kazuyoshi Kitaoka, Shiyori Kawata, Tomohiro Yoshida, Fumiya Kadoriku, Mitsuo Kitamura

published 21 Apr 2016

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Silymarin Constituent 2,3-Dehydrosilybin Triggers Reserpine-Sensitive Positive Inotropic Effect in Perfused Rat Heart

Eva Gabrielová, Aleksey Vladimirovich Zholobenko, Lenka Bartošíková, Jiří Nečas, Martin Modriansky

published 29 Sep 2015

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Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

Akina Harada, Kazunori Suzuki, Naomi Kamiguchi, Maki Miyamoto, Kimio Tohyama, Kosuke Nakashima, Takahiko Taniguchi, Haruhide Kimura

published 27 Mar 2015

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Identification and Characterization of a Novel Phosphodiesterase from the Metagenome of an Indian Coalbed

Durgesh Narain Singh, Ankush Gupta, Vijay Shankar Singh, Rajeev Mishra, Suneel Kateriya, Anil Kumar Tripathi

published 06 Feb 2015

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Comparative Effectiveness of Oral Drug Therapies for Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia: A Systematic Review and Network Meta-Analysis

Xinghuan Wang, Xiao Wang, Sheng Li, Zhe Meng, Tao Liu, Xinhua Zhang

published 12 Sep 2014

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PDE7B Is a Novel, Prognostically Significant Mediator of Glioblastoma Growth Whose Expression Is Regulated by Endothelial Cells

Michael D. Brooks, Erin Jackson, Nicole M. Warrington, Jingqin Luo, Jason T. Forys, Sara Taylor, Diane D. Mao, Jeffrey R. Leonard, Albert H. Kim, David Piwnica-Worms, Robi D. Mitra, Joshua B. Rubin

published 09 Sep 2014

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