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Pharmacokinetic analysis

Pharmacokinetic profiles of Moutan Cortex after single and repeated administration in a dinitrobenzene sulfonic acid-induced colitis model

Jin-Hwa Kim, Ji-Soo Jeong, Jeong-Won Kim, Eun-Hye Chung, Su-Ha Lee, Je-Won Ko, Youn-Hwan Hwang, Tae-Won Kim

published 02 Dec 2025

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Pharmacokinetic profile of oral firocoxib in the koala (Phascolarctos cinereus)

Amanda June Shapiro, Benjamin Kimble, Frances Hulst, Kimberly Vinette Herrin, Caroline Marschner, Chien-Jung Chen, Merran Govendir

published 30 Sep 2025

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Clinical safety and pharmacokinetics of a novel oral niclosamide formulation compared with marketed niclosamide chewing tablets in healthy volunteers: A three-part randomized, double-blind, placebo-controlled trial

Niklas Walther, Robert Schultz-Heienbrok, Heino Staß, Victor M. Corman, Nils C. Gassen, Marcel A. Müller, Christian Drosten, Martin Witzenrath, Hweeling Lee, Maximilian G. Posch

published 25 Feb 2025

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Platinum retention in plasma, urine, and normal colonic mucosa in cisplatin-treated testicular cancer survivors

Emilie C. H. Breekveldt, Berbel L. M. Ykema, Alwin D. R. Huitema, Jourik A. Gietema, Jos H. Beijnen, Petur Snaebjornsson, Michael Schaapveld, Flora E. van Leeuwen, Hilde Rosing, Monique E. van Leerdam, on behalf of the CATCHER study working group

published 14 Nov 2024

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Pembrolizumab 400 mg every 6 weeks as first-line therapy for advanced melanoma (KEYNOTE-555): Results from cohort B of an open-label, phase 1 study

Graham Cohen, Bernardo Rapoport, Sze W. Chan, Paul Ruff, Ana Arance, Karmele Mujika Eizmendi, Baerin Houghton, Michael P. Brown, Robert M. Zielinski, Eva Muñoz Couselo, Megan Lyle, James R. Anderson, Lokesh Jain, Dinesh de Alwis, Mallika Lala, Omobolaji Akala, Elliot Chartash, Conrad Jacobs

published 12 Nov 2024

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Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Sangavi Sivananthan, Varsha Bhakta, Negin Chaechi Tehrani, William P. Sheffield

published 23 Oct 2024

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In vivo pharmacokinetics of ginsenoside compound K mediated by gut microbiota

Ming-Si Deng, Su-tian-zi Huang, Ya-Ni Xu, Li Shao, Zheng-Guang Wang, Liang-Jian Chen, Wei-Hua Huang

published 23 Aug 2024

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GFR measurement in patients with CKD: Performance and feasibility of simplified iohexol plasma clearance techniques

Fabiola Carrara, Flavio Gaspari, Matias Trillini, Tobia Peracchi, Diego Fidone, Nadia Stucchi, Silvia Ferrari, Daniela Cugini, Norberto Perico, Aneliya Parvanova, Giuseppe Remuzzi, Piero Ruggenenti

published 17 Jul 2024

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Pharmacokinetics of isavuconazonium sulfate and its active metabolite isavuconazole in healthy dogs

Erin McQuinn, Jonathan P. Mochel, David Borts, Andrew S. Hanzlicek, Karin Allenspach, Jean-Sébastien Palerme

published 16 Jul 2024

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Discovery of allosteric regulators with clinical potential to stabilize alpha-L-iduronidase in mucopolysaccharidosis type I

Elena Cubero, Ana Ruano, Aida Delgado, Xavier Barril, Sara Morales, Ana Trapero, Lorenzo Leoni, Manolo Bellotto, Roberto Maj, Beatriz Calvo-Flores Guzmán, Natalia Pérez-Carmona, Ana Maria Garcia-Collazo

published 20 May 2024

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Impact of improved dead time correction on the quantification accuracy of a dedicated BrainPET scanner

Ahlam Said Mohamad Issa, Jürgen Scheins, Lutz Tellmann, Cláudia Régio Brambilla, Philipp Lohmann, Elena Rota-Kops, Hans Herzog, Irene Neuner, N. Jon Shah, Christoph Lerche

published 05 Apr 2024

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Pharmacokinetic and safety profiles of mesalazine enema in healthy Chinese subjects: A single- and multiple-dose study

Yuran Cao, Jingjing Wang, Xingyu Tang, Yan Tian, Jicheng Yu, Hong Liang, Jufang Wu, Yuancheng Chen, Guoying Cao, Jing Zhang

published 02 Feb 2024

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“Back to the future” projections for COVID-19 surges

J. Sunil Rao, Tianhao Liu, Daniel Andrés Díaz-Pachón

published 30 Jan 2024

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