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Pain management

Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol

Yi Zhang, Qiuxiang Chen, Yuanyuan Zhou, Qingjun Zeng, Haishan Cui, Yukai Zhou

published 15 May 2026

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The effectiveness of Chuna manual therapy based on radiographic malposition diagnosis in patients with non-acute low back pain: A study protocol for a randomized, assessor-blind, parallel-group, controlled trial

JungHo Jo, Yeong Ha Jeong, Tae-Yong Park, Young Cheol Na, Jun-Su Jang, Minho Choi, Junghan Lee, Kang-san Kim, Yoonhee Kim, Seungkwan Choi, Wonbae Ha, Jin-Hyun Lee

published 11 May 2026

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Non-concussive head impacts sustained during American football correlate with changes in gut microbiome diversity and composition

Zachary J. Pelland, Aziz Zafar, Ahmet A. Ay, Kenneth Douglas Belanger

published 06 May 2026

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Neurological events and unanticipated risks after locoregional anesthesia (NEURAL): Protocol for a multicenter prospective observational study

Alessandro De Cassai, Elena Ioppolo, Dario Bugada, Francesco Tasso, Gianluca Cappelleri, Vito Torrano

published 05 May 2026

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Characterizing complex opioid use disorder care trajectories and outcomes following acute service utilization: A protocol for a population-based data linkage study

Noa Krawczyk, Ignacio Bórquez, Megan Miller, Sung Woo Lim, Teena Cherian, Daniel Schatz, Alex Harocopos, Emily Carter, Marc Scott, Brandy F. Henry, David Frank, Magdalena Cerdá, Arthur Robin Williams

published 30 Apr 2026

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Criterion validity and divergent risk profiles of long-term opioid therapy across medicare and medicaid

Robert W. Hurley, Daniel Guth, Elaine L. Hill, Meredith C. B. Adams

published 29 Apr 2026

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Evaluation and enhancement of suspected opioid overdose definitions in emergency medical services data using machine learning with natural language processing

Peter Rock, Svetla Slavova, Sharon L. Walsh, Julia Martin, Daniel R. Harris

published 28 Apr 2026

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A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models

Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada, Takehiko Asaga, Norio Suzuki, Masayuki Yamamoto, Yuichi Ogino, Gotaro Shirakami, Akira Nishiyama

published 21 Apr 2026

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Evaluation of AT121 versus morphine on cortical neurons electrophysiology and dopamine concentrations in hippocampal cells

Baraa E. Elawy, Chadi E. Soukkarieh, Abdul Q. Abbady, Shaza A. Allaham, Georges M. Deeb

published 20 Apr 2026

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A systematic review protocol: Efficacy and safety of nitrous oxide in analgesia in burn patients with dressing change

Weifeng Wang, Xianli Meng, Yan Zhao, Wei Gong, Xiaochen Jiang, Wenjuan Cao, Xueling Qiu, Chenxi Sun, Fan Sun, Yuchen Wang, Lu Tang

published 17 Apr 2026

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High-versus conventional-volume pericapsular nerve group (PENG) block for total hip arthroplasty: A randomized, controlled trial

Qian-song Wang, Shi-ming Qin, Yang Zhao, Chong-mei Gao, Xia Yuan, Zhao-hui Chen

published 17 Apr 2026

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Prevalence, predictors, and clinical relevance of drug–drug interactions in outpatient prescribing: A national cross-sectional study

Seyed Sahab Aarabi, Farbod Semnani, Zahra Aminzade, Reza Mehrizi, Mohammad Gholamnezhad, Raham Armand, Nezam Armand, Leila Ghamkhar

published 08 Apr 2026

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Evaluation of medetomidine-tiletamine-zolazepam as a partially reversible field anesthesia combination for mesocarnivores

Fernando Nájera, Jamie L. Palmer, Stella F. Uiterwaal, Parami Peiris, Manuel Mata-Huete, Juan Francisco Sánchez, María Jesús Palacios, Rebeca Grande-Gómez, Luis Revuelta Rueda, Esther Descalzo, Jose Jimenez, Pablo Ferreras, Sharon L. Deem

published 07 Apr 2026

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