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Oxidoreductases

A chemically optimized, GalNAc-conjugated siRNA targeting HSD17B13 demonstrates efficacy in a human 3D organoid model of MASH, showcasing an alternative to animal testing

Qin Meng, Xujia Wang, Yuxuan Zhang, Sudeep Pushpakom, Jun Yang, Hui Feng, Mu Wang

published 14 Aug 2026

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Tyro3 facilitates cytoplasmic delivery of extracellular vesicle contents and antigen presentation via major histocompatibility complex class I in dendritic cells

Takashi Koyama, Katsuhiko Kojima, Koki Maeda, Takahide Matsui, Hitomi Kosai, Noriko Ishida, Eiji Morita, Mitsunori Fukuda, Nobuyuki Tanaka

published 04 Aug 2026

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Engineering of episomal plasmid structure to enhance non-viral Poly(beta-amino ester) nanoparticle gene delivery to liver and brain cancer cells

Joanna Yang, Jack Kollings, Ethan Idnani, David R. Wilson, Isabella G. Cozzone, Shanelle Mendes, Mahita Varanasi, Stephany Y. Tzeng, Jordan J. Green

published 23 Jul 2026

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TBX20 promotes doxorubicin resistance in breast cancer cells through enhanced ABCC1 expression and inhibition of mitophagy

Shuai Nie, Dejian Liu, Jun Hu, Yu Gan, Liangliang Mi

published 17 Jul 2026

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Isoginkgetin increases the expression of metal responsive transcripts but inhibits their translation

Claire Peneycad, Erin van Zyl, Abhinav Mohur, Bruce C. McKay

published 25 Jun 2026

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Enhanced IGFL1 translation in response to IL-1β is controlled by distinct 3’UTR elements

Giulia Cardamone, Melanie Flohr, Rebecca Raue, Irina Bode, Sofie P. Meyer, Sven Hauns, Rolf Backofen, Tobias Schmid

published 25 Jun 2026

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Bisphenol BPAF and BPC are agonists for estrogen receptor ERα but antagonists for N-terminal domain-lacking ERα

Xiaohui Liu, Miki Shimohigashi, Yasuyuki Shimohigashi

published 01 Jun 2026

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The inhibitors of miR-224-5p, miR-339-5p, and miR-1198-5p improve auditory function by promoting the expression of neuritin in hearing loss mice

Pingping Meng, Zhiwei Zhong, Yin Song, Yu Wei, Jiawei Sun, Jingyi Chen, Yunhua Zhang, Jingling Zhu

published 21 May 2026

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The RNA helicase eIF4A as a novel target in insect cells to combat arboviral infections

Tanja Rehling, Kim Mentchen, Leonie Konopka, Wiebke Obermann, Friedemann Weber, Patrick Schmerer, Marc F. Schetelig, Arnold Grünweller, Irina Häcker, Francesca Magari

published 06 Apr 2026

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Development of immortalized Callithrix jacchus kidney cell lines supporting infection with a panel of viruses

Sabine Gärtner, Pamela Stomberg, Stefan Pöhlmann, Michael Winkler

published 02 Mar 2026

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An upstream secondary DNA motif within the IL3 insulator CTCF binding site is required for enhancer-blocking insulator activity

Sarion R. Bowers, Peter N. Cockerill

published 09 Feb 2026

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Structural flexibility of the nicotinamide group of NADH in butanol dehydrogenase YqdH from Fusobacterium nucleatum

Xue Bai, Ki Hyun Nam, Yongbin Xu

published 17 Dec 2025

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Inflammatory cytokines promote interferon regulatory factor (IRF) transcriptional activity in human pulmonary epithelial cells through the induction of IRF1 by nuclear factor-κB

Amandah Necker-Brown, Mahmoud M. Mostafa, Andrei Georgescu, Andrew J. Thorne, Priyanka Chandramohan, Cora Kooi, Keerthana Kalyanaraman, Alex Gao, Akanksha Bansal, Sarah K. Sasse, Anthony N. Gerber, Richard Leigh, Robert Newton

published 08 Dec 2025

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