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Mouse models

Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175^+/- mouse model of Huntington’s Disease

Joseph W. Goodliffe, Hanbing Song, [ ... ], Jennifer I. Luebke

Antihyperuricemic and xanthine oxidase inhibitory activities of Tribulus arabicus and its isolated compound, ursolic acid: In vitro and in vivo investigation and docking simulations

Eman Abu-Gharbieh, Naglaa G. Shehab, Ihab M. Almasri, Yasser Bustanji

Deubiquitinase inhibitor PR-619 reduces Smad4 expression and suppresses renal fibrosis in mice with unilateral ureteral obstruction

Kotaro Soji, Shigehiro Doi, [ ... ], Takao Masaki

Activation of Nrf2 in the liver is associated with stress resistance mediated by suppression of the growth hormone-regulated STAT5b transcription factor

John Rooney, Keiyu Oshida, [ ... ], J. Christopher Corton

Striatal transcriptome of a mouse model of ADHD reveals a pattern of synaptic remodeling

Anastasia M. Sorokina, Michael Saul, [ ... ], Justin S. Rhodes

Researchers’ attitudes to the 3Rs—An upturned hierarchy?

Nuno Henrique Franco, Peter Sandøe, I. Anna S. Olsson

Neuroinflammation and ER-stress are key mechanisms of acute bilirubin toxicity and hearing loss in a mouse model

Emanuele Schiavon, Joshua L. Smalley, [ ... ], Ian D. Forsythe

Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acids

Keita Watanabe, Miki Igarashi, [ ... ], Ikuo Kimura

The effect of Tmem135 overexpression on the mouse heart

Sarah Aileen Lewis, Tetsuya Takimoto, [ ... ], Akihiro Ikeda

TAK-272 (imarikiren), a novel renin inhibitor, improves cardiac remodeling and mortality in a murine heart failure model

Tomoya Hara, Satoshi Nishimura, [ ... ], Tomoyuki Nishimoto

Differential effects of angiotensin II type I receptor blockers on reducing intraocular pressure and TGFβ signaling in the mouse retina

Ralph J. Hazlewood, Qingxia Chen, [ ... ], Rachel W. Kuchtey

Neurog3 misexpression unravels mouse pancreatic ductal cell plasticity

Andhira Vieira, Bastien Vergoni, [ ... ], Patrick Collombat

Presenilin1 regulates Th1 and Th17 effector responses but is not required for experimental autoimmune encephalomyelitis

Matthew Cummings, Anitha Christy Sigamani Arumanayagam, [ ... ], Todd N. Eagar

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