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Motor neuron diseases

Retrospective analysis of neurofilament-light chain in patients with inflammatory bowel disease – A pilot study

Andreas Wolff, Emily Feneberg, Julius Shakhtour, Katja Steiger, Roland M. Schmid, Bernhard Haller, Nya Reinhardt, Moritz Middelhoff, David Schult-Hannemann, Paul Lingor

published 29 Jan 2026

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Polygenic associations with clinical and neuropathological trait heterogeneity across TDP-43 proteinopathies

Barbara E. Spencer, David J. Irwin, Vivianna M. Van Deerlin, EunRan Suh, Edward B. Lee, Lauren Elman, Colin C. Quinn, Defne Amado, Michael Baer, Murray Grossman, David A. Wolk, Corey T. McMillan

published 30 Dec 2025

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Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study

Natalie Saunders, Claire Magnussen, HyungMo Kang, Mathieu Blais, Harpreet Bhinder, Gerald Pfeffer, Shelagh K. Genuis, Liziane Bouvier, Tanushka Anand, Rida Abou-Haidar, Agessandro Abrahao, Marie-Noëlle Boivin, Robert Bowser, Tania Bubela, Julia Chiappini, Samir Das, Avnit Dhanoa, Nicolas Dupré, Alan Evans, Nicolas Ferry, Yvonne Frater, Angela Genge, Simon J. Graham, Russell Greiner, Yasser Iturria Medina, Wendy S. Johnston, Kelvin E. Jones, Jason Karamchandani, Jasna Kriz, Westerly Luth, Geneviève Matte, Ekaterina Rogaeva, Janice Robertson, Peter Seres, Fred Tam, David Taylor, Clémence Tremblay-Desbiens, Christine Vande Velde, Yana Yunusova, Lorne Zinman, Sanjay Kalra

published 04 Dec 2025

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A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis

Christian Marius Lillelund, Sanjay Kalra, Russell Greiner, The Pooled Resource Open-Access ALS Clinical Trials Consortium (PRO-ACT)

published 18 Nov 2025

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Exposure to the organochlorine pesticide cis-chlordane induces ALS-like mitochondrial perturbations in stem cell-derived motor neurons

Oliver Clackson, Muhammad Reza Hamid, Adithi Wijesekera, Daniel Kulick, Alison Linsley O’Neil

published 14 Oct 2025

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An Evaluation of the United Kingdom Motor Neuron Disease Nurses and Allied Health Professionals (UK MND NAHP) Workforce: A Census

Isaac Chau, Ethan Stoker, Jessica Gill, Judith Newton, on behalf of The United Kingdom Motor Neuron Disease Nurses and Allied Health Professionals Consortium

published 11 Jul 2025

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Interventions to improve awareness and reduce the stigma associated with neurodegenerative conditions in minority ethnic communities: A scoping review protocol

Maria Caulfield, Sahdia Parveen, Matthew Prina, Jan R Oyebode, Karen Windle, Catherine Charlwood, Adelina Comas-Herrera, Catherine Quinn, Linda Clare

published 07 May 2025

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Muscle strengthening in individuals with Amyotrophic Lateral Sclerosis: a systematic review with meta-analyses

Aline Alves de Souza, Stephano Tomaz da Silva, Amanda Mayra Pereira Régis, Diogo Neres Aires, Karen de Medeiros Pondofe, Luciana Protásio de Melo, Ricardo Alexsandro de Medeiros Valentim, Ana Raquel Rodrigues Lindquist, Lorenna Raquel Dantas de Macedo, Tatiana Souza Ribeiro

published 24 Apr 2025

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Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons

Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

published 18 Mar 2025

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In vivo mapping of sodium homeostasis disturbances in individual ALS patients: A brain ²³Na MRI study

Aude-Marie Grapperon, Mohamed Mounir El Mendili, Adil Maarouf, Jean-Philippe Ranjeva, Maxime Guye, Annie Verschueren, Shahram Attarian, Wafaa Zaaraoui

published 22 Jan 2025

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SEMdag: Fast learning of Directed Acyclic Graphs via node or layer ordering

Mario Grassi, Barbara Tarantino

published 08 Jan 2025

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Deciphering the interactome of Ataxin-2 and TDP-43 in iPSC-derived neurons for potential ALS targets

Yuan Tian, Nicolette Heinsinger, Yinghui Hu, U-Ming Lim, Yi Wang, Aaron Zefrin Fernandis, Sophie Parmentier-Batteur, Becky Klein, Jason M. Uslaner, Sean M. Smith

published 31 Dec 2024

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Methods to normalize surface electromyography in respiratory muscles: Is it similar between amyotrophic lateral sclerosis and healthy people?

Thiago Bezerra Wanderley e Lima, Jessica Danielle Medeiros da Fonseca, Ana Aline Marcelino da Silva, Rayane Grayce da Silva Vieira, Dayane Montemezzo, Matias Otto-Yáñez, Rodrigo Torres-Castro, Mário Emílio Teixeira Dourado Júnior, Vanessa Regiane Resqueti, Guilherme Augusto de Freitas Fregonezi

published 20 Dec 2024

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