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Molecular development

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Ramesh Narayanan, Muralimohan Yepuru, Christopher C. Coss, Zhongzhi Wu, Matthew N. Bauler, Christina M. Barrett, Michael L. Mohler, Yun Wang, Juhyun Kim, Linda M. Snyder, Yali He, Nelson Levy, Duane D. Miller, James T. Dalton

published 26 Dec 2013

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IL-17A Induces Endothelial Inflammation in Systemic Sclerosis via the ERK Signaling Pathway

Xiaojing Xing, Ji Yang, Xiaoqin Yang, Yi Wei, Lubing Zhu, Di Gao, Ming Li

published 23 Dec 2013

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CD44-Deficiency Attenuates the Immunologic Responses to LPS and Delays the Onset of Endotoxic Shock-Induced Renal Inflammation and Dysfunction

Elena Rampanelli, Mark C. Dessing, Nike Claessen, Gwendoline J. D. Teske, Sander P. J. Joosten, Steven T. Pals, Jaklien C. Leemans, Sandrine Florquin

published 23 Dec 2013

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Defining the Role of Fluid Shear Stress in the Expression of Early Signaling Markers for Calcific Aortic Valve Disease

Ling Sun, Nalini M. Rajamannan, Philippe Sucosky

published 23 Dec 2013

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Estrogen-Induced Nongenomic Calcium Signaling Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor α Production in Macrophages

Limin Liu, Ying Zhao, Keming Xie, Xiaodong Sun, Yuzhen Gao, Zufeng Wang

published 23 Dec 2013

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ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation

Adrian Nahirnyj, Izhar Livne-Bar, Xiaoxin Guo, Jeremy M. Sivak

published 23 Dec 2013

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FJU-C4, a New 2-Pyridone Compound, Attenuates Lipopolysaccharide-Induced Systemic Inflammation via p38MAPK and NF-κB in Mice

Jung-Sen Liu, Fang Jung, Shih-Hsing Yang, Shang-Shing P. Chou, Jhih-Liang Huang, Chang-Lin Lu, Guan-Lin Huang, Pan-Chyr Yang, Jau-Chen Lin, Guey-Mei Jow

published 23 Dec 2013

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SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

Crystal Rocher, Dinender K. Singla

published 20 Dec 2013

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Evidence of Infectious Asthma Phenotype: Chlamydia-Induced Allergy and Pathogen-Specific IgE in a Neonatal Mouse Model

Katir K. Patel, Wilmore C. Webley

published 20 Dec 2013

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A Mechanochemical Model for Embryonic Pattern Formation: Coupling Tissue Mechanics and Morphogen Expression

Moritz Mercker, Dirk Hartmann, Anna Marciniak-Czochra

published 20 Dec 2013

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Regulation of Development of CD56^brightCD11c⁺ NK-like Cells with Helper Function by IL-18

Wen Li, Akico Okuda, Hideyuki Yamamoto, Kyosuke Yamanishi, Nobuyuki Terada, Hiromichi Yamanishi, Yoshimasa Tanaka, Haruki Okamura

published 20 Dec 2013

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IL-10 Is Significantly Involved in HSP70-Regulation of Experimental Subretinal Fibrosis

Yang Yang, Atsunobu Takeda, Takeru Yoshimura, Yuji Oshima, Koh-Hei Sonoda, Tatsuro Ishibashi

published 20 Dec 2013

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Borrelia burgdorferi Elicited-IL-10 Suppresses the Production of Inflammatory Mediators, Phagocytosis, and Expression of Co-Stimulatory Receptors by Murine Macrophages and/or Dendritic Cells

Yutein Chung, Nan Zhang, R. Mark Wooten

published 19 Dec 2013

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