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Molecular development

Discovery and Preclinical Characterization of Novel Small Molecule TRK and ROS1 Tyrosine Kinase Inhibitors for the Treatment of Cancer and Inflammation

Ramesh Narayanan, Muralimohan Yepuru, [ ... ], James T. Dalton

IL-17A Induces Endothelial Inflammation in Systemic Sclerosis via the ERK Signaling Pathway

Xiaojing Xing, Ji Yang, [ ... ], Ming Li

CD44-Deficiency Attenuates the Immunologic Responses to LPS and Delays the Onset of Endotoxic Shock-Induced Renal Inflammation and Dysfunction

Elena Rampanelli, Mark C. Dessing, [ ... ], Sandrine Florquin

Defining the Role of Fluid Shear Stress in the Expression of Early Signaling Markers for Calcific Aortic Valve Disease

Ling Sun, Nalini M. Rajamannan, Philippe Sucosky

Estrogen-Induced Nongenomic Calcium Signaling Inhibits Lipopolysaccharide-Stimulated Tumor Necrosis Factor α Production in Macrophages

Limin Liu, Ying Zhao, [ ... ], Zufeng Wang

ROS Detoxification and Proinflammatory Cytokines Are Linked by p38 MAPK Signaling in a Model of Mature Astrocyte Activation

Adrian Nahirnyj, Izhar Livne-Bar, Xiaoxin Guo, Jeremy M. Sivak

FJU-C4, a New 2-Pyridone Compound, Attenuates Lipopolysaccharide-Induced Systemic Inflammation via p38MAPK and NF-κB in Mice

Jung-Sen Liu, Fang Jung, [ ... ], Guey-Mei Jow

SMAD-PI3K-Akt-mTOR Pathway Mediates BMP-7 Polarization of Monocytes into M2 Macrophages

Crystal Rocher, Dinender K. Singla

Evidence of Infectious Asthma Phenotype: Chlamydia-Induced Allergy and Pathogen-Specific IgE in a Neonatal Mouse Model

Katir K. Patel, Wilmore C. Webley

A Mechanochemical Model for Embryonic Pattern Formation: Coupling Tissue Mechanics and Morphogen Expression

Moritz Mercker, Dirk Hartmann, Anna Marciniak-Czochra

Regulation of Development of CD56^brightCD11c⁺ NK-like Cells with Helper Function by IL-18

Wen Li, Akico Okuda, [ ... ], Haruki Okamura

IL-10 Is Significantly Involved in HSP70-Regulation of Experimental Subretinal Fibrosis

Yang Yang, Atsunobu Takeda, [ ... ], Tatsuro Ishibashi

Borrelia burgdorferi Elicited-IL-10 Suppresses the Production of Inflammatory Mediators, Phagocytosis, and Expression of Co-Stimulatory Receptors by Murine Macrophages and/or Dendritic Cells

Yutein Chung, Nan Zhang, R. Mark Wooten

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