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Microsomes

The N-terminus of Sec61p plays key roles in ER protein import and ERAD

Francesco Elia, Lalitha Yadhanapudi, Thomas Tretter, Karin Römisch

published 24 Apr 2019

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Validated LC-MS/MS assay for quantification of the newly approved tyrosine kinase inhibitor, dacomitinib, and application to investigating its metabolic stability

Ali S. Abdelhameed, Adnan A. Kadi, Mohamed W. Attwa, Haitham AlRabiah

published 04 Apr 2019

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Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation

Fabio Pereira, Mandy Rettel, Frank Stein, Mikhail M. Savitski, Ian Collinson, Karin Römisch

published 25 Jan 2019

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Use of a sequential high throughput screening assay to identify novel inhibitors of the eukaryotic SRP-Sec61 targeting/translocation pathway

Wolfgang Klein, Claudia Rutz, Jamina Eckhard, Becky Provinciael, Edgar Specker, Martin Neuenschwander, Gunnar Kleinau, Patrick Scheerer, Jens-Peter von Kries, Marc Nazaré, Kurt Vermeire, Ralf Schülein

published 13 Dec 2018

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Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Hao Sun, David W. Piotrowski, Suvi T. M. Orr, Joseph S. Warmus, Angela C. Wolford, Steven B. Coffey, Kentaro Futatsugi, Yinsheng Zhang, Alfin D. N. Vaz

published 14 Nov 2018

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Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization

Danielle McAnally, Khandaker Siddiquee, Ahmed Gomaa, Andras Szabo, Stefan Vasile, Patrick R. Maloney, Daniela B. Divlianska, Satyamaheshwar Peddibhotla, Camilo J. Morfa, Paul Hershberger, Rebecca Falter, Robert Williamson, David B. Terry, Rafal Farjo, Anthony B. Pinkerton, Xiaping Qi, Judith Quigley, Michael E. Boulton, Maria B. Grant, Layton H. Smith

published 12 Sep 2018

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The JAK2/STAT3 inhibitor pacritinib effectively inhibits patient-derived GBM brain tumor initiating cells in vitro and when used in combination with temozolomide increases survival in an orthotopic xenograft model

Katharine Victoria Jensen, Orsolya Cseh, Ahmed Aman, Samuel Weiss, Hema Artee Luchman

published 18 Dec 2017

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Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway

Ibrahim El-Serafi, Ylva Terelius, Manuchehr Abedi-Valugerdi, Seán Naughton, Maryam Saghafian, Ali Moshfegh, Jonas Mattsson, Zuzana Potácová, Moustapha Hassan

published 09 Nov 2017

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Effect of erythropoietin administration on proteins participating in iron homeostasis in Tmprss6-mutated mask mice

Jana Frýdlová, Zuzana Rychtarčíková, Iuliia Gurieva, Martin Vokurka, Jaroslav Truksa, Jan Krijt

published 26 Oct 2017

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Chemical crosslinking and mass spectrometry to elucidate the topology of integral membrane proteins

Mykhaylo O. Debelyy, Patrice Waridel, Manfredo Quadroni, Roger Schneiter, Andreas Conzelmann

published 26 Oct 2017

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Feeding-fasting dependent recruitment of membrane microdomain proteins to lipid droplets purified from the liver

Kritika Sadh, Priyanka Rai, Roop Mallik

published 11 Aug 2017

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Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders

Bitna Yi, Alam Jahangir, Andrew K. Evans, Denise Briggs, Kristine Ravina, Jacqueline Ernest, Amir B. Farimani, Wenchao Sun, Jayakumar Rajadas, Michael Green, Evan N. Feinberg, Vijay S. Pande, Mehrdad Shamloo

published 26 Jul 2017

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Identification of benzazole compounds that induce HIV-1 transcription

Jason D. Graci, Daniel Michaels, Guangming Chen, Gillian M. Schiralli Lester, Sarah Nodder, Marla Weetall, Gary M. Karp, Zhengxian Gu, Joseph M. Colacino, Andrew J. Henderson

published 28 Jun 2017

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