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Macromolecular engineering

Protein Trans-Splicing of an Atypical Split Intein Showing Structural Flexibility and Cross-Reactivity

Huiling Song, Qing Meng, Xiang-Qin Liu

published 14 Sep 2012

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Complex Structure of Engineered Modular Domains Defining Molecular Interaction between ICAM-1 and Integrin LFA-1

Sungkwon Kang, Chae Un Kim, Xiaoling Gu, Roisin M. Owens, Sarah J. van Rijn, Vanissra Boonyaleepun, Yuxin Mao, Timothy A. Springer, Moonsoo M. Jin

published 30 Aug 2012

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The PLOS ONE Synthetic Biology Collection: Six Years and Counting

Jean Peccoud, Mark Isalan

published 15 Aug 2012

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An Automated Flow for Directed Evolution Based on Detection of Promiscuous Scaffolds Using Spatial and Electrostatic Properties of Catalytic Residues

Sandeep Chakraborty

published 11 Jul 2012

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Structure of an Engineered β-Lactamase Maltose Binding Protein Fusion Protein: Insights into Heterotropic Allosteric Regulation

Wei Ke, Abigail H. Laurent, Morgan D. Armstrong, Yuchao Chen, William E. Smith, Jing Liang, Chapman M. Wright, Marc Ostermeier, Focco van den Akker

published 14 Jun 2012

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Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard, Gilles Mourier, Guillaume Blanchet, Laura Vera, Nicolas Gilles, Renée Ménez, Elodie Marcon, Enrico A. Stura, Denis Servent

published 14 Jun 2012

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Circular Permutation in the Ω-Loop of TEM-1 β-Lactamase Results in Improved Activity and Altered Substrate Specificity

Gurkan Guntas, Manu Kanwar, Marc Ostermeier

published 19 Apr 2012

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Incorporation of Noncanonical Amino Acids into Rosetta and Use in Computational Protein-Peptide Interface Design

P. Douglas Renfrew, Eun Jung Choi, Richard Bonneau, Brian Kuhlman

published 14 Mar 2012

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Engineered Protein Nano-Compartments for Targeted Enzyme Localization

Swati Choudhary, Maureen B. Quin, Mark A. Sanders, Ethan T. Johnson, Claudia Schmidt-Dannert

published 12 Mar 2012

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Directed Evolution of the Transcriptional Regulator DntR: Isolation of Mutants with Improved DNT-Response

Rosa Lönneborg, Edina Varga, Peter Brzezinski

published 19 Jan 2012

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Stabilisation of the Fc Fragment of Human IgG1 by Engineered Intradomain Disulfide Bonds

Gordana Wozniak-Knopp, Johannes Stadlmann, Florian Rüker

published 17 Jan 2012

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A Thermostable β-Glucuronidase Obtained by Directed Evolution as a Reporter Gene in Transgenic Plants

Ai-Sheng Xiong, Ri-He Peng, Jing Zhuang, Jian-Min Chen, Bin Zhang, Jian Zhang, Quan-Hong Yao

published 09 Nov 2011

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The Molecular Basis for the Broad Substrate Specificity of Human Sulfotransferase 1A1

Ilana Berger, Chen Guttman, Dotan Amar, Raz Zarivach, Amir Aharoni

published 01 Nov 2011

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