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Macromolecular engineering

Pharmacological characterization of potent and selective Na_V1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V

Bryan D. Moyer, Justin K. Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, John B. Jordan, Josie H. Lee, Dong Liu, Jason Long, Kelvin Sham, Licheng Shi, Reto Stöcklin, Bin Wu, Ruoyuan Yin, Violeta Yu, Anruo Zou, Kaustav Biswas, Les P. Miranda

published 03 May 2018

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Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system

Kristin Støen Gunnarsen, Lene Støkken Høydahl, Ralf Stefan Neumann, Kaare Bjerregaard-Andersen, Nicolay Rustad Nilssen, Ludvig Magne Sollid, Inger Sandlie, Geir Åge Løset

published 12 Apr 2018

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ProtDataTherm: A database for thermostability analysis and engineering of proteins

Hassan Pezeshgi Modarres, Mohammad R. Mofrad, Amir Sanati-Nezhad

published 29 Jan 2018

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An L213A variant of β-glycosidase from Sulfolobus solfataricus with increased α-L-arabinofuranosidase activity converts ginsenoside Rc to compound K

Ji-Hyeon Choi, Kyung-Chul Shin, Deok-Kun Oh

published 11 Jan 2018

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Screening of transporters to improve xylodextrin utilization in the yeast Saccharomyces cerevisiae

Chenlu Zhang, Ligia Acosta-Sampson, Vivian Yaci Yu, Jamie H. D. Cate

published 08 Sep 2017

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Directed evolution provides insight into conformational substrate sampling by SrtA

Muna Suliman, Vishaka Santosh, Tom C. M. Seegar, Annamarie C. Dalton, Kathryn M. Schultz, Candice S. Klug, William A. Barton

published 31 Aug 2017

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Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis

Wenjie Li, Shouteng Xu, Biao Zhang, Yelin Zhu, Yan Hua, Xin Kong, Lianhong Sun, Jiong Hong

published 22 May 2017

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Computational prediction of the tolerance to amino-acid deletion in green-fluorescent protein

Eleisha L. Jackson, Stephanie J. Spielman, Claus O. Wilke

published 03 Apr 2017

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Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity

Yi Shen, Yingche Chen, Jiahui Wu, Nathan C. Shaner, Robert E. Campbell

published 27 Feb 2017

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Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution

Hye-Young Sagong, Kyung-Jin Kim

published 17 Jan 2017

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Kinetic Controlled Tag-Catcher Interactions for Directed Covalent Protein Assembly

Lee Ling Tan, Shawn S. Hoon, Fong T. Wong

published 26 Oct 2016

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Improving the Thermostability of Acidic Pullulanase from Bacillus naganoensis by Rational Design

Meihui Chang, Xiaoyu Chu, Jinzhi Lv, Qingbin Li, Jian Tian, Ningfeng Wu

published 20 Oct 2016

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Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding

David Paramelle, Tao Peng, Paul Free, David G. Fernig, Sierin Lim, Nikodem Tomczak

published 13 Sep 2016

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