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Macromolecular engineering

Rosetta:MSF:NN: Boosting performance of multi-state computational protein design with a neural network

Julian Nazet, Elmar Lang, Rainer Merkl

published 26 Aug 2021

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Discovery of potent and specific inhibitors targeting the active site of MMP-9 from the engineered SPINK2 library

Hidenori Yano, Daisuke Nishimiya, Yoshirou Kawaguchi, Masakazu Tamura, Ryuji Hashimoto

published 29 Dec 2020

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5,5-Dialkylluciferins are thermal stable substrates for bioluminescence-based detection systems

Ce Shi, Michael P. Killoran, Mary P. Hall, Paul Otto, Monika G. Wood, Ethan Strauss, Lance P. Encell, Thomas Machleidt, Keith V. Wood, Thomas A. Kirkland

published 14 Dec 2020

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Improved yellow-green split fluorescent proteins for protein labeling and signal amplification

Shuqin Zhou, Siyu Feng, David Brown, Bo Huang

published 23 Nov 2020

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SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity

Derek Cerchione, Katherine Loveluck, Eric L. Tillotson, Fred Harbinski, Jen DaSilva, Chase P. Kelley, Elise Keston-Smith, Cecilia A. Fernandez, Vic E. Myer, Hariharan Jayaram, Barrett E. Steinberg

published 16 Apr 2020

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Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

published 09 Apr 2020

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Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins

Zeyu Peng, Maria D. R. Peralta, Daniel L. Cox, Michael D. Toney

published 21 Feb 2020

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Occurrence and stability of hetero-hexamer associations formed by β-carboxysome CcmK shell components

Luis F. Garcia-Alles, Katharina Root, Laurent Maveyraud, Nathalie Aubry, Eric Lesniewska, Lionel Mourey, Renato Zenobi, Gilles Truan

published 11 Oct 2019

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Posterior ventral tegmental area-nucleus accumbens shell circuitry modulates response to novelty

Hailong Li, Jessica M. Illenberger, Michael N. Cranston, Charles F. Mactutus, Kristen A. McLaurin, Steven B. Harrod, Rosemarie M. Booze

published 05 Mar 2019

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu

published 28 Dec 2018

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The scale-free nature of protein sequence space

Patrick C. F. Buchholz, Catharina Zeil, Jürgen Pleiss

published 01 Aug 2018

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Next generation calmodulin affinity purification: Clickable calmodulin facilitates improved protein purification

Julia G. Fraseur, Tamara L. Kinzer-Ursem

published 04 Jun 2018

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Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Allison R. Sirois, Daniela A. Deny, Samantha R. Baierl, Katia S. George, Sarah J. Moore

published 08 May 2018

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