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Lysosomes

Immune-Mediated Inflammation May Contribute to the Pathogenesis of Cardiovascular Disease in Mucopolysaccharidosis Type I

Omar Khalid, Moin U. Vera, [ ... ], Raymond Y. Wang

Geranylated 4-Phenylcoumarins Exhibit Anticancer Effects against Human Prostate Cancer Cells through Caspase-Independent Mechanism

Noor Shahirah Suparji, Gomathi Chan, [ ... ], Noor Hasima Nagoor

Exogenous Thyropin from p41 Invariant Chain Diminishes Cysteine Protease Activity and Affects IL-12 Secretion during Maturation of Human Dendritic Cells

Tina Zavašnik-Bergant, Martina Bergant Marušič

The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization

Vasileios A. Stamelos, Natalie Fisher, [ ... ], Alan Richardson

HIV Impairs Lung Epithelial Integrity and Enters the Epithelium to Promote Chronic Lung Inflammation

Kieran A. Brune, Fernanda Ferreira, [ ... ], Venkataramana K. Sidhaye

Lipoprotein X Causes Renal Disease in LCAT Deficiency

Alice Ossoli, Edward B. Neufeld, [ ... ], Alan T. Remaley

T47D Cells Expressing Myeloperoxidase Are Able to Process, Traffic and Store the Mature Protein in Lysosomes: Studies in T47D Cells Reveal a Role for Cys³¹⁹ in MPO Biosynthesis that Precedes Its Known Role in Inter-Molecular Disulfide Bond Formation

Richard P. Laura, David Dong, Wanda F. Reynolds, Richard A. Maki

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation

Jason K. Cullen, Norazian Abdul Murad, [ ... ], Martin F. Lavin

CRYβA3/A1-Crystallin Knockout Develops Nuclear Cataract and Causes Impaired Lysosomal Cargo Clearance and Calpain Activation

Shylaja Hegde, Robert A. Kesterson, Om P. Srivastava

A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion

Magdalena L. Circu, Samantha S. Dykes, [ ... ], Hazem El-Osta

Molecular Determinants of GS-9620-Dependent TLR7 Activation

Indrani Rebbapragada, Gabriel Birkus, [ ... ], Stefan Pflanz

Gpnmb Is a Potential Marker for the Visceral Pathology in Niemann-Pick Type C Disease

André R. A. Marques, Tanit L. Gabriel, [ ... ], Marco van Eijk

The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages

Arwa Abu Khweek, Apurva Kanneganti, Denis C. Guttridge D, Amal O. Amer

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