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Lysosomes

Multi-omics analysis and single-cell sequencing revealed the lysosome associated molecular subtypes and prognostic model development of papillary thyroid carcinoma

Jianhua Zhang, Kai Yue, Yansheng Wu, Chao Jing, Xudong Wang

published 10 Jun 2025

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Autophagy across tissues of aging mice

Julian M. Carosi, Alexis Martin, Leanne K. Hein, Sofia Hassiotis, Kathryn J. Hattersley, Bradley J. Turner, Célia Fourrier, Julien Bensalem, Timothy J. Sargeant

published 04 Jun 2025

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AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, Mugdha Deshpande, Shin-ichi Matsumoto, Miyu Nakayama, Syunsuke Yamamoto, Bettina Strack-Logue, Takeshi Hioki, Maiko Tanaka, Gabriele Proetzel

published 07 May 2025

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Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition

Jinghui Zhang, Xusheng Chang, Yingcheng Bai, Xiancai Ge, Kai Yin, Qun Xin

published 02 May 2025

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Chemigenetic Ca²⁺ indicators report elevated Ca²⁺ levels in endothelial Weibel-Palade bodies

Julian Terglane, Nicole Mertes, Sarah Weischer, Thomas Zobel, Kai Johnsson, Volker Gerke

published 27 Jan 2025

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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B. Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E. Crawford, Stuart Bunting, Mika Aoyagi-Scharber

published 03 Jan 2025

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St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo

Yanxia Guo, Shikang Wang, Qun Liu, Yan Dong, Yongqing Liu

published 27 Dec 2024

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In vitro safety evaluation of dopamine D₃R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

published 16 Dec 2024

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

Lisa Marie P. Evans, Joseph Gawron, Fraser J. Sim, M. Laura Feltri, Leandro N. Marziali

published 05 Dec 2024

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Pharmacokinetic evaluation of single-dose migalastat in non-Fabry disease subjects with ESRD receiving dialysis treatment, and use of modeling to select dose regimens in Fabry disease subjects with ESRD receiving dialysis treatment

Franklin K. Johnson, Shirley Wu, Ginny Schmith, Hadis Williams, Jasmine Rutecki, Atef Halabi, Thorsten Feldkamp, Anthony Sileno

published 05 Dec 2024

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An automated high-content screening and assay platform for the analysis of spheroids at subcellular resolution

Margaritha M. Mysior, Jeremy C. Simpson

published 12 Nov 2024

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Growth on stiffer substrates impacts animal health and longevity in C. elegans

Maria Oorloff, Adam Hruby, Maxim Averbukh, Athena Alcala, Naibedya Dutta, Cray Minor, Toni Castro Torres, Darius Moaddeli, Matthew Vega, Juri Kim, Andrew Bong, Aeowynn J. Coakley, Daniel Hicks, Jing Wang, Tiffany Wang, Sally Hoang, Kevin M. Tharp, Gilberto Garcia, Ryo Higuchi-Sanabria

published 12 Sep 2024

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Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma

Michael A. Sun, Haipei Yao, Qing Yang, Christopher J. Pirozzi, Vidyalakshmi Chandramohan, David M. Ashley, Yiping He

published 20 Mar 2024

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