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Library screening

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Thomas S. Peat, David I. Rhodes, Nick Vandegraaff, Giang Le, Jessica A. Smith, Lisa J. Clark, Eric D. Jones, Jonathan A. V. Coates, Neeranat Thienthong, Janet Newman, Olan Dolezal, Roger Mulder, John H. Ryan, G. Paul Savage, Craig L. Francis, John J. Deadman

published 10 Jul 2012

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High-throughput Screening and Sensitized Bacteria Identify an M. tuberculosis Dihydrofolate Reductase Inhibitor with Whole Cell Activity

Anuradha Kumar, Meng Zhang, Linyun Zhu, Reiling P. Liao, Charles Mutai, Shittu Hafsat, David R. Sherman, Ming-Wei Wang

published 29 Jun 2012

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A FRET-Based High Throughput Screening Assay to Identify Inhibitors of Anthrax Protective Antigen Binding to Capillary Morphogenesis Gene 2 Protein

Michael S. Rogers, Lorna M. Cryan, Kaiane A. Habeshian, Lauren Bazinet, Thomas P. Caldwell, P. Christine Ackroyd, Kenneth A. Christensen

published 29 Jun 2012

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Functional Metagenomics Unveils a Multifunctional Glycosyl Hydrolase from the Family 43 Catalysing the Breakdown of Plant Polymers in the Calf Rumen

Manuel Ferrer, Azam Ghazi, Ana Beloqui, José María Vieites, Nieves López-Cortés, Julia Marín-Navarro, Taras Y. Nechitaylo, María-Eugenia Guazzaroni, Julio Polaina, Agnes Waliczek, Tatyana N. Chernikova, Oleg N. Reva, Olga V. Golyshina, Peter N. Golyshin

published 25 Jun 2012

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Characterization of Human DNA Polymerase Delta and Its Subassemblies Reconstituted by Expression in the Multibac System

Yajing Zhou, Xiao Meng, Sufang Zhang, Ernest Y. C. Lee, Marietta Y. W. T. Lee

published 18 Jun 2012

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A Two-Step Target Binding and Selectivity Support Vector Machines Approach for Virtual Screening of Dopamine Receptor Subtype-Selective Ligands

Jingxian Zhang, Bucong Han, Xiaona Wei, Chunyan Tan, Yuzong Chen, Yuyang Jiang

published 15 Jun 2012

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Application of Consensus Scoring and Principal Component Analysis for Virtual Screening against β-Secretase (BACE-1)

Shu Liu, Rao Fu, Li-Hua Zhou, Sheng-Ping Chen

published 11 Jun 2012

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Peripheral Nervous System Genes Expressed in Central Neurons Induce Growth on Inhibitory Substrates

William J. Buchser, Robin P. Smith, Jose R. Pardinas, Candace L. Haddox, Thomas Hutson, Lawrence Moon, Stanley R. Hoffman, John L. Bixby, Vance P. Lemmon

published 06 Jun 2012

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A Novel RNAi Lethality Rescue Screen to Identify Regulators of Adipogenesis

Olivier van Beekum, Yuan Gao, Ruud Berger, Arjen Koppen, Eric Kalkhoven

published 05 Jun 2012

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The Oncoprotein BCL11A Binds to Orphan Nuclear Receptor TLX and Potentiates its Transrepressive Function

Sara B. Estruch, Víctor Buzón, Laia R. Carbó, Lenka Schorova, Jens Lüders, Eva Estébanez-Perpiñá

published 04 Jun 2012

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The Alström Syndrome Protein, ALMS1, Interacts with α-Actinin and Components of the Endosome Recycling Pathway

Gayle B. Collin, Jan D. Marshall, Benjamin L. King, Gabriella Milan, Pietro Maffei, Daniel J. Jagger, Jürgen K. Naggert

published 31 May 2012

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ANKRD26 and Its Interacting Partners TRIO, GPS2, HMMR and DIPA Regulate Adipogenesis in 3T3-L1 Cells

Xiu-Fen Liu, Tapan K. Bera, Charissa Kahue, Thelma Escobar, Zhaoliang Fei, Gregory A. Raciti, Ira Pastan

published 30 May 2012

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Isolation and Characterisation of a Human-Like Antibody Fragment (scFv) That Inactivates VEEV In Vitro and In Vivo

Torsten Rülker, Luzie Voß, Philippe Thullier, Lyn M. O' Brien, Thibaut Pelat, Stuart D. Perkins, Claudia Langermann, Thomas Schirrmann, Stefan Dübel, Hans-Jürgen Marschall, Michael Hust, Birgit Hülseweh

published 30 May 2012

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