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Ion channels

L-type calcium channel blocker increases VEGF concentrations in retinal cells and human serum

Anmol Kumar, Stefan Mutter, Erika B. Parente, Valma Harjutsalo, Raija Lithovius, Sinnakaruppan Mathavan, Markku Lehto, Timo P. Hiltunen, Kimmo K. Kontula, Per-Henrik Groop

published 13 Apr 2023

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Benzonatate as a local anesthetic

Anna McGuire, Claire A. Ostertag-Hill, Gil Aizik, Yang Li, Daniel S. Kohane

published 12 Apr 2023

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Purification and biochemical analysis of native AMPA receptors from three different mammalian species

Prashant Rao, Eric Gouaux

published 17 Mar 2023

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Action potential metrics and automated data analysis pipeline for cardiotoxicity testing using optically mapped hiPSC-derived 3D cardiac microtissues

Arvin H. Soepriatna, Allison Navarrete-Welton, Tae Yun Kim, Mark C. Daley, Peter Bronk, Celinda M. Kofron, Ulrike Mende, Kareen L. K. Coulombe, Bum-Rak Choi

published 06 Feb 2023

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Not so optimal: The evolution of mutual information in potassium voltage-gated channels

Alejandra Duran-Urriago, Sarah Marzen

published 03 Feb 2023

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Electrophysiological evaluation of an anticancer drug gemcitabine on cardiotoxicity revealing down-regulation and modification of the activation gating properties in the human rapid delayed rectifier potassium channel

Mengyan Wei, Pu Wang, Xiufang Zhu, Masaki Morishima, Yangong Liu, Mingqi Zheng, Gang Liu, Hiroki Osanai, Kenshi Yoshimura, Shinichiro Kume, Tatsuki Kurokawa, Katsushige Ono

published 02 Feb 2023

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Ectodomain shedding of EGFR ligands serves as an activation readout for TRP channels

Manae Tatsumi, Takayuki Kishi, Satoru Ishida, Hiroki Kawana, Akiharu Uwamizu, Yuki Ono, Kouki Kawakami, Junken Aoki, Asuka Inoue

published 20 Jan 2023

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Spatiotemporal patterns of early afterdepolarizations underlying abnormal T-wave morphologies in a tissue model of the Purkinje-ventricular system

Mengya Yuan, Heqiang Lian, Pan Li

published 09 Jan 2023

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Differential protein expression of GABA A receptor alpha 1 subunit and calbindin in rat spermatozoa associated with proteomic analysis in testis following methamphetamine administration

Paweena Kaewman, Sutisa Nudmamud-Thanoi, Jitnapar Thongleart, Sawanya Charoenlappanit, Sittiruk Roytrakul, Samur Thanoi

published 04 Jan 2023

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RC-4BC cells express nicotinic and muscarinic acetylcholine receptors

Gulsamal Zhubanova, Olena Filchakova

published 16 Dec 2022

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Targeted deep sequencing analyses of long QT syndrome in a Japanese population

Yuki Nagata, Ryo Watanabe, Christian Eichhorn, Seiko Ohno, Takeshi Aiba, Taisuke Ishikawa, Yukiko Nakano, Yoshiyasu Aizawa, Kenshi Hayashi, Nobuyuki Murakoshi, Tadashi Nakajima, Nobue Yagihara, Hiroyuki Mishima, Takeaki Sudo, Chihiro Higuchi, Atsushi Takahashi, Akihiro Sekine, Takeru Makiyama, Yoshihiro Tanaka, Atsuyuki Watanabe, Motomi Tachibana, Hiroshi Morita, Koh-ichiro Yoshiura, Tatsuhiko Tsunoda, Hiroshi Watanabe, Masahiko Kurabayashi, Akihiko Nogami, Yasuki Kihara, Minoru Horie, Wataru Shimizu, Naomasa Makita, Toshihiro Tanaka

published 08 Dec 2022

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GluR2^Q and GluR2^R AMPA Subunits are not Targets of lypd2 Interaction

Anna Lauriello, Quinn McVeigh, Rou-Jia Sung

published 28 Nov 2022

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Peptide Lv augments intermediate-conductance calcium-dependent potassium channels (K_Ca3.1) in endothelial cells to promote angiogenesis

Dylan L. Pham, Autumn Niemi, Michael L. Ko, Gladys Y. P. Ko

published 25 Oct 2022

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