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Induced pluripotent stem cells

Characterization of DNA methylation in PBMCs and donor-matched iPSCs shows age-related methylation is reset during stem cell reprogramming

Xylena Reed, Cory A. Weller, Sara Saez-Atienzar, Alexandra Beilina, Sultana Solaiman, Makayla Portley, Mary Kaileh, Roshni Roy, Jinhui Ding, A. Zenobia Moore, D. Thad Whitaker, Bryan J. Traynor, Luigi Ferrucci, J. Raphael Gibbs, Sonja W. Scholz, Mark R. Cookson

published 08 Sep 2026

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A phase I clinical trial to evaluate the tolerability and safety of an allogeneic iPSC-derived iNKT cell and α-GalCer-pulsed autologous DC combination therapy for patients with recurrent and advanced head and neck cancer: A study protocol

Tomoya Kurokawa, Tomohisa Iinuma, Haruna Ebisu, Tomoha Yanagidaira, Yosuke Inaba, Tadami Fujiwara, Yoko Hattori, Tominaga Fukazawa, Takahiro Aoki, Haruhiko Koseki, Hideki Hanaoka, Toyoyuki Hanazawa, Shinichiro Motohashi

published 26 Feb 2026

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N-glycosylation of NANOG regulates stemness and apoptosis in colon cancer cells

Yin Tian, Yu Zeng, Yun Liu, Jun Ye, Xin Zhang

published 20 Nov 2025

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Gene electrotransfer with flow-through microchannel and lower alternating voltage generated induced pluripotent cells from human lymphoblastoid cell lines

Miho Ishii-Teshima, Koki Maeda, Kazuki Hanauchi, Emika Asechi, Defan Setyawan, Takeshi Niki, Kenji Nakashima, Hirofumi Kurita, Rika Numano, Takayuki Shibata

published 26 Sep 2025

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Antibodies raised against a structurally defined Aβ oligomer mimic protect human iPSC neurons from Aβ toxicity at sub-stoichiometric concentrations

Sarah M. Ruttenberg, Rakia Dhaoui, Adam G. Kreutzer, James S. Nowick

published 08 Sep 2025

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Incorporation of iPSCs together with TERT-immortalized keratinocytes and fibroblasts into reconstructed human gingiva enhances phenotype of gingival epithelium

Lisa-Lee Brueske, Sanne Roffel, Stephanie Beekhuis-Hoekstra, Helga E. de Vries, Susan Gibbs

published 21 Jul 2025

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The Wnt pathway induces a naïve-like subpopulation in primed stem cells, while NME7_AB leads to a homogeneous naïve-like population

Kevin R. Yi, Jac-Leen S.S. Nash, Mark G. Carter, Danica M. Walkley, Jiwon Jang, Benoit J. Smagghe, Andrew K. Stewart, Cynthia C. Bamdad

published 25 Jun 2025

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Non-viral derivation of induced pluripotent stem cells from the canine umbilical cord

Atsushi Yamazaki, Seiji Shiozawa, Yuko Koushige, Hirotaka Kondo, Hisashi Shibuya, Kazuya Edamura

published 18 Jun 2025

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Comparative analysis of extracellular vesicles from induced and adipose-derived Mesenchymal Stem Cells: Implications for regenerative medicine

Sura Nashwan, Mohammad A. Ismail, Tareq Saleh, Sabal Al Hadidi, Enas Alwohoush, Momen Sarhan, Nizar Abu Harfeil, Abdalla Awidi, Nidaa A. Ababneh

published 04 Jun 2025

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A human iPSC-derived midbrain neural stem cell model of prenatal opioid exposure and withdrawal: A proof of concept study

Rhea Sullivan, Quinn Ahrens, Sara L. Mills-Huffnagle, Irina A. Elcheva, Steven D. Hicks

published 01 Apr 2025

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Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol

Colin E. Swenson, William R. Hunt, Candela Manfredi, Diana J. Beltran, Jeong S. Hong, Brian R. Davis, Shingo Suzuki, Cristina Barillá, Andras Rab, Cynthia Chico, Joy Dangerfield, Ashleigh Streby, Erin Barton, Elizabeth M. Cox, Arlene A. Stecenko, Adrianna Westbrook, Rebecca Kapolka, Eric J. Sorscher

published 14 Feb 2025

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A NOTCH3 pathogenic variant influences osteogenesis and can be targeted by antisense oligonucleotides in induced pluripotent stem cells

Ernesto Canalis, Jungeun Yu, Lauren Schilling, Paymaan Jafar-nejad, Michele Carrer

published 03 Jan 2025

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Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

Lisa Marie P. Evans, Joseph Gawron, Fraser J. Sim, M. Laura Feltri, Leandro N. Marziali

published 05 Dec 2024

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