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Hydroxylation

Identification of the Lomofungin Biosynthesis Gene Cluster and Associated Flavin-Dependent Monooxygenase Gene in Streptomyces lomondensis S015

Chunxiao Zhang, Chaolan Sheng, Wei Wang, Hongbo Hu, Huasong Peng, Xuehong Zhang

published 25 Aug 2015

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Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain

Mun Chiang Chan, Onur Atasoylu, Emma Hodson, Anthony Tumber, Ivanhoe K. H. Leung, Rasheduzzaman Chowdhury, Verónica Gómez-Pérez, Marina Demetriades, Anna M. Rydzik, James Holt-Martyn, Ya-Min Tian, Tammie Bishop, Timothy D. W. Claridge, Akane Kawamura, Christopher W. Pugh, Peter J. Ratcliffe, Christopher J. Schofield

published 06 Jul 2015

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Antioxidant Activity of Caffeic Acid against Iron-Induced Free Radical Generation—A Chemical Approach

Thiago C. Genaro-Mattos, Ângelo Q. Maurício, Daniel Rettori, Antonio Alonso, Marcelo Hermes-Lima

published 22 Jun 2015

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Myeloid Translocation Gene-16 Co-Repressor Promotes Degradation of Hypoxia-Inducible Factor 1

Parveen Kumar, Urban Gullberg, Inge Olsson, Ram Ajore

published 14 May 2015

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The Toluene o-Xylene Monooxygenase Enzymatic Activity for the Biosynthesis of Aromatic Antioxidants

Giuliana Donadio, Carmen Sarcinelli, Elio Pizzo, Eugenio Notomista, Alessandro Pezzella, Carlo Di Cristo, Federica De Lise, Alberto Di Donato, Viviana Izzo

published 27 Apr 2015

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In Vitro and In Vivo Metabolism and Inhibitory Activities of Vasicine, a Potent Acetylcholinesterase and Butyrylcholinesterase Inhibitor

Wei Liu, Xiaoyuan Shi, Yadi Yang, Xuemei Cheng, Qing Liu, Han Han, Baohua Yang, Chunyong He, Yongli Wang, Bo Jiang, Zhengtao Wang, Changhong Wang

published 07 Apr 2015

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Prediction of Overall In Vitro Microsomal Stability of Drug Candidates Based on Molecular Modeling and Support Vector Machines. Case Study of Novel Arylpiperazines Derivatives

Szymon Ulenberg, Mariusz Belka, Marek Król, Franciszek Herold, Weronika Hewelt-Belka, Agata Kot-Wasik, Tomasz Bączek

published 31 Mar 2015

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YCZ-18 Is a New Brassinosteroid Biosynthesis Inhibitor

Keimei Oh, Tadashi Matsumoto, Ayumi Yamagami, Atushi Ogawa, Kazuhiro Yamada, Ryuichiro Suzuki, Takayuki Sawada, Shozo Fujioka, Yuko Yoshizawa, Takeshi Nakano

published 20 Mar 2015

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Intermediary Metabolite Precursor Dimethyl-2-Ketoglutarate Stabilizes Hypoxia-Inducible Factor-1α by Inhibiting Prolyl-4-Hydroxylase PHD2

Peifeng Hou, Ching-Ying Kuo, Chun-Ting Cheng, Jing-Ping Liou, David K. Ann, Qiang Chen

published 24 Nov 2014

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Dihydroflavonol 4-Reductase Genes Encode Enzymes with Contrasting Substrate Specificity and Show Divergent Gene Expression Profiles in Fragaria Species

Silvija Miosic, Jana Thill, Malvina Milosevic, Christian Gosch, Sabrina Pober, Christian Molitor, Shaghef Ejaz, Annette Rompel, Karl Stich, Heidi Halbwirth

published 13 Nov 2014

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Identification and Characterization of a New Erythromycin Biosynthetic Gene Cluster in Actinopolyspora erythraea YIM90600, a Novel Erythronolide-Producing Halophilic Actinomycete Isolated from Salt Field

Dandan Chen, Junyin Feng, Lei Huang, Qinglin Zhang, Jiequn Wu, Xiangcheng Zhu, Yanwen Duan, Zhinan Xu

published 24 Sep 2014

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Structure-Function Analysis of Porcine Cytochrome P450 3A29 in the Hydroxylation of T-2 Toxin as Revealed by Docking and Mutagenesis Studies

Guyue Cheng, Changcun Liu, Xu Wang, Hongmin Ma, Yuanhu Pan, Lingli Huang, Haihong Hao, Menghong Dai, Zonghui Yuan

published 03 Sep 2014

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A Systems Biology-Based Approach to Uncovering the Molecular Mechanisms Underlying the Effects of Dragon's Blood Tablet in Colitis, Involving the Integration of Chemical Analysis, ADME Prediction, and Network Pharmacology

Haiyu Xu, Yanqiong Zhang, Yun Lei, Xiumei Gao, Huaqiang Zhai, Na Lin, Shihuan Tang, Rixin Liang, Yan Ma, Defeng Li, Yi Zhang, Guangrong Zhu, Hongjun Yang, Luqi Huang

published 28 Jul 2014

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