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Huntington disease

MR-based spatial normalization improves [¹⁸F]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington’s disease

Daniele Bertoglio, Jeroen Verhaeghe, Lauren Kosten, David Thomae, Annemie Van der Linden, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens

published 26 Oct 2018

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Differential changes to D1 and D2 medium spiny neurons in the 12-month-old Q175^+/- mouse model of Huntington’s Disease

Joseph W. Goodliffe, Hanbing Song, Anastasia Rubakovic, Wayne Chang, Maria Medalla, Christina M. Weaver, Jennifer I. Luebke

published 17 Aug 2018

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Sexual behavior and testis morphology in the BACHD rat model

Arianna Novati, Libo Yu-Taeger, Irene Gonzalez Menendez, Leticia Quintanilla Martinez, Huu Phuc Nguyen

published 08 Jun 2018

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Does arterial hypertension influence the onset of Huntington's disease?

Leire Valcárcel-Ocete, Asier Fullaondo, Gorka Alkorta-Aranburu, María García-Barcina, Raymund A. C. Roos, Lena E. Hjermind, Carsten Saft, Marina Frontali, Ralf Reilmann, Hugh Rickards, The REGISTRY investigators of the European Huntington’s Disease Network (EHDN) , Ana M. Zubiaga, Ana Aguirre

published 23 May 2018

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Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

Mijung Lee, Jae-Jun Ban, Jin-Young Chung, Wooseok Im, Manho Kim

published 09 May 2018

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A novel ex vivo Huntington’s disease model for studying GABAergic neurons and cell grafts by laser microdissection

E. M. André, N. Daviaud, L. Sindji, J. Cayon, R. Perrot, C. N. Montero-Menei

published 05 Mar 2018

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Premanifest Huntington’s disease: Examination of oculomotor abnormalities in clinical practice

Jessica Y. Winder, Raymund A. C. Roos

published 01 Mar 2018

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Cerebrospinal fluid sCD27 levels indicate active T cell-mediated inflammation in premanifest Huntington's disease

Valter Niemelä, Joachim Burman, Kaj Blennow, Henrik Zetterberg, Anders Larsson, Jimmy Sundblom

published 23 Feb 2018

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BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates

Giuseppe Manfré, Arianna Novati, Ilaria Faccini, Andrea C. Rossetti, Kari Bosch, Raffaella Molteni, Marco A. Riva, Johanneke E. Van der Harst, Huu Phuc Nguyen, Judith R. Homberg

published 07 Feb 2018

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MicroRNA signatures of endogenous Huntingtin CAG repeat expansion in mice

Peter Langfelder, Fuying Gao, Nan Wang, David Howland, Seung Kwak, Thomas F. Vogt, Jeffrey S. Aaronson, Jim Rosinski, Giovanni Coppola, Steve Horvath, X. William Yang

published 11 Jan 2018

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Quantification of huntingtin protein species in Huntington’s disease patient leukocytes using optimised electrochemiluminescence immunoassays

Davina J. Hensman Moss, Nicola Robertson, Ruth Farmer, Rachael I. Scahill, Salman Haider, Michela A. Tessari, Geraldine Flynn, David F. Fischer, Edward J. Wild, Douglas Macdonald, Sarah J. Tabrizi

published 22 Dec 2017

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Behavioral testing of minipigs transgenic for the Huntington gene—A three-year observational study

Verena Schuldenzucker, Robin Schubert, Lisa M. Muratori, Frauke Freisfeld, Lorena Rieke, Tamara Matheis, Sarah Schramke, Jan Motlik, Nicole Kemper, Ute Radespiel, Ralf Reilmann

published 09 Oct 2017

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Changes in striatal activity and functional connectivity in a mouse model of Huntington's disease

Magali Cabanas, Fares Bassil, Nicole Mons, Maurice Garret, Yoon H. Cho

published 21 Sep 2017

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