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Heterocyclic compounds

Matrix stiffness influences drug resistance to gemcitabine analog and AZD 1775 combination in PDAC organoids

Jonathan Barajas, Zhi Yang, Edward Agyare, Xueyou Zhu, Saun-Joo Yoon, Bo Han

published 04 Dec 2025

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Bacimethrin, an allelopathic vitamin B₁ antagonist, is linked with microbial gene expression patterns in a hypereutrophic watershed

Kelly C. Shannon, Frederick S. Colwell, Byron C. Crump, Elizabeth Brennan, Gillian St. John, Robin Gould, Christopher Hartzell, McKenzie Wasley, Christie Nichols, Clifford E. Kraft, Christopher P. Suffridge

published 21 Nov 2025

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Evaluation of the expression pattern of TIAs pathway genes in response to tryptophan amino acid treatment and drought stress in Catharanthus roseus

Farshid Yousefi, Alireza Abdali Mashhadi, Amin Lotfi Jalal Abadi, Alireza Shafeinia, Saied Jalily, Narges Soltani

published 09 Oct 2025

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Novel thiazole derivatives as effective anti-cancer agents against human osteosarcoma cell line (SaOS-2): Microwave-assisted one-pot three-component synthesis, in vitro anti-cancer studies, and in silico investigations

Arif Mermer, Aydın Tahmasebifar, Sami A. Al-Hussain, Gizem Tatar Yılmaz, Zeynep Dilan Turgut, Aqsa Mushtaq, Ameer Fawad Zahoor, Ali Irfan, Magdi E. A. Zaki

published 26 Aug 2025

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Impact of predicted microbiota tryptophanase activity on Cryptosporidium parvum proliferation

Debora Regina Romualdo da Silva, Xiaojiao Yang, Giovanni Widmer

published 13 Jun 2025

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Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults: A single-arm clinical trial

Toshiaki Tokumaru, Tadashi Toyama, Yusuke Nakade, Hisayuki Ogura, Megumi Oshima, Shiori Nakagawa, Masashi Mita, Taro Miyagawa, Shinji Kitajima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Yasunori Iwata, Takashi Wada

published 03 Jun 2025

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Fragment-based drug discovery for transthyretin kinetic stabilisers using a novel capillary zone electrophoresis method

Wenjie Chen

published 14 May 2025

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Identification of MsCYP79 and MsCYP83 gene families and its response to mechanical damage in Medicago sativa L.

Fang Wu, Jing Zhang, Hongshan Yang, Huirong Duan

published 08 May 2025

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Molecular simulation-based investigation of thiazole derivatives as potential LasR inhibitors of Pseudomonas aeruginosa

Snigdha Bhardwaj, Kandasamy Nagarajan, Halima Mustafa Elagib, Sadaf Anwar, Mohammad Zeeshan Najm, Tulika Bhardwaj, Mohd Adnan Kausar

published 22 Apr 2025

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Proteomic characterization of clinical Candida glabrata isolates with varying degrees of virulence and resistance to fluconazole

Pamela El Khoury, Ahmad Zeidan, Roy A. Khalaf

published 25 Mar 2025

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Synthesis, antibacterial activity, in silico ADMET prediction, docking, and molecular dynamics studies of substituted phenyl and furan ring containing thiazole Schiff base derivatives

Md. Din Islam, Joyanta Kumar Saha, Sumita Saznin Marufa, Tanmoy Kumar Kundu, Ismail Hossain, Hiroshi Nishino, Mohammad Sayed Alam, Md. Aminul Haque, Mohammad Mostafizur Rahman

published 10 Mar 2025

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Cracking susceptibility of full-sibs of a cross of a cracking tolerant and cracking susceptible sweet cherry: Relation to cuticle characteristics, microcracking and calcium

Moritz Knoche, Loise Grosset-Grange, José Quero-García, David Alletru, Lina Boutaleb

published 03 Jan 2025

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Synergistic potential of lopinavir and azole combinational therapy against clinically important Aspergillus species

Nicolas Burns, Ehab A. Salama, Mohamed N. Seleem

published 02 Dec 2024

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