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Genetically modified animals

RIO-kinase 2 is essential for hematopoiesis

Jan-Erik Messling, Isabel Peña-Rømer, Ann Sophie Moroni, Sarah Bruestl, Kristian Helin

published 02 Apr 2024

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Novel insights into RAGE signaling pathways during the progression of amyotrophic lateral sclerosis in RAGE-deficient SOD1 G93A mice

Natalia Nowicka, Kamila Zglejc-Waszak, Judyta Juranek, Agnieszka Korytko, Krzysztof Wąsowicz, Małgorzata Chmielewska-Krzesińska, Joanna Wojtkiewicz

published 08 Mar 2024

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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model

Winston T. Stauffer, Asha Z. Goodman, Michael Bobardt, Daren R. Ure, Robert T. Foster, Philippe Gallay

published 01 Mar 2024

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The PINK1/Parkin pathway of mitophagy exerts a protective effect during prion disease

Anne Ward, Forrest Jessop, Robert Faris, Jason Hollister, Daniel Shoup, Brent Race, Catharine M. Bosio, Suzette A. Priola

published 23 Feb 2024

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High frequency of germline recombination in Nestin-Cre transgenic mice crossed with Glucagon-like peptide 1 receptor floxed mice

Yusuke Kajitani, Takashi Miyazawa, Tomoaki Inoue, Nao Kajitani, Masamichi Fujita, Yukina Takeichi, Yasutaka Miyachi, Ryuichi Sakamoto, Yoshihiro Ogawa

published 20 Dec 2023

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Two mouse models of Alzheimer’s disease accumulate amyloid at different rates and have distinct Aβ oligomer profiles unaltered by ablation of cellular prion protein

Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark Farrow, Andrew J. Nicoll, Dominic Walsh, John Collinge

published 17 Nov 2023

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Female sex protects against renal edema, but not lung edema, in mice with partial deletion of the endothelial barrier regulator Tie2 compared to male sex

Anoek L. I. van Leeuwen, Elise Beijer, Roselique Ibelings, Nicole A. M. Dekker, Marjolein R. A. van der Steen, Joris J. T. H. Roelofs, Matijs van Meurs, Grietje Molema, Charissa E. van den Brom

published 16 Nov 2023

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Development of a sensitive real-time quaking-induced conversion (RT-QuIC) assay for application in prion-infected blood

Charlotte M. Thomas, M. Khalid F. Salamat, Christopher de Wolf, Sandra McCutcheon, A. Richard Alejo Blanco, Jean C. Manson, Nora Hunter, E. Fiona Houston

published 02 Nov 2023

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Exercise performance is not improved in mice with skeletal muscle deletion of natriuretic peptide clearance receptor

Brigitte Jia, Alexander Hasse, Fubiao Shi, Sheila Collins

published 02 Nov 2023

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U-Net based vessel segmentation for murine brains with small micro-magnetic resonance imaging reference datasets

Christoph Praschl, Lydia M. Zopf, Emma Kiemeyer, Ines Langthallner, Daniel Ritzberger, Adrian Slowak, Martin Weigl, Valentin Blüml, Nebojša Nešić, Miloš Stojmenović, Kathrin M. Kniewallner, Ludwig Aigner, Stephan Winkler, Andreas Walter

published 12 Oct 2023

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Type 1 diabetes contributes to combined pulmonary fibrosis and emphysema in male alpha 1 antitrypsin deficient mice

Sangmi S. Park, Michelle Mai, Magdalena Ploszaj, Huchong Cai, Lucas McGarvey, Christian Mueller, Itsaso Garcia-Arcos, Patrick Geraghty

published 11 Oct 2023

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Hydroxyurea does not reverse functional alterations of the nitric oxide-cGMP pathway associated with priapism phenotype in corpus cavernosum from sickle cell mouse

Dalila Andrade Pereira, Danillo Andrade Pereira, Pamela da Silva Pereira, Tammyris Helena Rebecchi Silveira, Fabiano Beraldi Calmasini, Leonardo Oliveira Reis, Fernando Ferreira Costa, Fábio Henrique Silva

published 09 Oct 2023

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Long term survival and abnormal liver fat accumulation in mice with specific thymidine kinase 2 deficiency in liver tissue

Qian Zhao, Xiaoshan Zhou, Jingyi Yan, Raoul Kuiper, Sophie Curbo, Anna Karlsson

published 05 Oct 2023

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