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Genetically modified animals

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice

Barkha J. Yadav-Samudrala, Hailey Dodson, Shreya Ramineni, Elizabeth Kim, Justin L. Poklis, Dai Lu, Bogna M. Ignatowska-Jankowska, Aron H. Lichtman, Sylvia Fitting

published 24 Jun 2024

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Dietary intervention rescues a bone porosity phenotype in a murine model of Neurofibromatosis Type 1 (NF1)

Alexandra K. O’Donohue, Xiaoying C. Li, Lucinda R. Lee, Emily R. Vasiljevski, David G. Little, Craig F. Munns, Aaron Schindeler

published 24 Jun 2024

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Revisiting the NPcis mouse model: A new tool to model plexiform neurofibroma

Camille Plante, Teddy Mohamad, Dhanushka Hewa Bostanthirige, Michel Renaud, Harsimran Sidhu, Michel ElChoueiry, Jean-Paul Sabo Vatasescu, Mikael Poirier, Sameh Geha, Jean-Philippe Brosseau

published 20 Jun 2024

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An oral toxicity assessment of a mosquito larvicidal transgenic algae (Chlamydomonas reinhardtii) using adult Zebrafish and its embryos

Fareeha Amjad, Hamza Khan, Muhammad Islam Khan, Sidra Ayub, Rashid Bhatti, Rabbia Pervaiz, Kausar Malik, Mohsin Ahmad Khan

published 13 Jun 2024

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Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions

Jonathan M. Alektiar, Mengrou Shan, Megan D. Radyk, Li Zhang, Christopher J. Halbrook, Lin Lin, Carlos Espinoza, Ivan F. Mier, Brooke L. Lavoie, Lucie Salvatore, Marina Pasca di Magliano, Lewis C. Cantley, Jacob L. Mueller, Costas A. Lyssiotis

published 06 Jun 2024

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Dach1 is essential for maintaining normal mature podocytes

Keiko Tanaka, Haruko Hayasaka, Taiji Matsusaka

published 28 May 2024

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Pseudopregnant mice generated from Piwil1 deficiency sterile mice

Shuoshuo Xie, Ruixin Qin, Wentao Zeng, Jianmin Li, Yana Lai

published 21 May 2024

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Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy

Jinli Wang, Daniel A. Lai, Joshua J. Wang, Sarah X. Zhang

published 15 May 2024

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Downregulation of SOX9 expression in developing entheses adjacent to intramembranous bone

Asahi Kitamura, Masahito Yamamoto, Hidetomo Hirouchi, Genji Watanabe, Shuichiro Taniguchi, Sayo Sekiya, Satoshi Ishizuka, Juhee Jeong, Kazunari Higa, Shuichiro Yamashita, Shinichi Abe

published 10 May 2024

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The uterine secretome initiates growth of gynecologic tissues in ectopic locations

Jan Sunde, Morgan Wasickanin, Tiffany A. Katz, Laurel Gillette, Sanam Bidadi, Derek O’Neil, Ramya Masand, Richard O. Burney, Kathleen A. Pennington

published 10 May 2024

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HIF3A gene disruption causes abnormal alveoli structure and early neonatal death

Tomoki Kawahata, Kitaru Tanaka, Kyohei Oyama, Jun Ueda, Kensaku Okamoto, Yuichi Makino

published 08 May 2024

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Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice

Gholson J. Lyon, Joseph Longo, Andrew Garcia, Fatima Inusa, Elaine Marchi, Daniel Shi, Max Dörfel, Thomas Arnesen, Rafael Aldabe, Scott Lyons, Melissa A. Nashat, David Bolton

published 07 May 2024

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DFMG decreases angiogenesis to uphold plaque stability by inhibiting the TLR4/VEGF pathway in mice

Pingjuan Bai, Xueping Xiang, Jiawen Kang, Xiaoqing Xiang, Jingwen Jiang, Xiaohua Fu, Yong Zhang, Lesai Li

published 18 Apr 2024

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