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Genetically modified animals

Autophagy Limits Endotoxemic Acute Kidney Injury and Alters Renal Tubular Epithelial Cell Cytokine Expression

Jeremy S. Leventhal, Jie Ni, Morgan Osmond, Kyung Lee, G. Luca Gusella, Fadi Salem, Michael J. Ross

published 18 Mar 2016

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Preclinical Investigations of PM01183 (Lurbinectedin) as a Single Agent or in Combination with Other Anticancer Agents for Clear Cell Carcinoma of the Ovary

Ryoko Takahashi, Seiji Mabuchi, Mahiru Kawano, Tomoyuki Sasano, Yuri Matsumoto, Hiromasa Kuroda, Katsumi Kozasa, Kae Hashimoto, Kenjiro Sawada, Tadashi Kimura

published 17 Mar 2016

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Foxn1 Is Dynamically Regulated in Thymic Epithelial Cells during Embryogenesis and at the Onset of Thymic Involution

Kathy E. O’Neill, Nicholas Bredenkamp, Christin Tischner, Harsh J. Vaidya, Frances H. Stenhouse, C. Diana Peddie, Craig S. Nowell, Terri Gaskell, C. Clare Blackburn

published 16 Mar 2016

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CD117⁺ Dendritic and Mast Cells Are Dependent on RasGRP4 to Function as Accessory Cells for Optimal Natural Killer Cell-Mediated Responses to Lipopolysaccharide

Saijun Zhou, Kumiko Tanaka, Meredith O’Keeffe, Miao Qi, Fatima El-Assaad, James C. Weaver, Gang Chen, Christopher Weatherall, Ying Wang, Bill Giannakopoulos, Liming Chen, DeMint Yu, Matthew J. Hamilton, Lislaine A. Wensing, Richard L. Stevens, Steven A. Krilis

published 16 Mar 2016

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Mechanosensory and ATP Release Deficits following Keratin14-Cre-Mediated TRPA1 Deletion Despite Absence of TRPA1 in Murine Keratinocytes

Katherine J. Zappia, Sheldon R. Garrison, Oleg Palygin, Andy D. Weyer, Marie E. Barabas, Michael W. Lawlor, Alexander Staruschenko, Cheryl L. Stucky

published 15 Mar 2016

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Vascular Endothelial Growth Factor (VEGF) Bioavailability Regulates Angiogenesis and Intestinal Stem and Progenitor Cell Proliferation during Postnatal Small Intestinal Development

Christopher R. Schlieve, Salvador Garcia Mojica, Kathleen A. Holoyda, Xiaogang Hou, Kathryn L. Fowler, Tracy C. Grikscheit

published 15 Mar 2016

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Generation of Mice with Hepatocyte-Specific Conditional Deletion of Notum

Frédéric Canal, Sara Charawi, Gisèle Grimber, Christophe Houbron, Valérie Drouet, Sabine Colnot, Benoit Terris, Catherine Cavard, Christine Perret

published 14 Mar 2016

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Safety Evaluation of Neo Transgenic Pigs by Studying Changes in Gut Microbiota Using High-Throughput Sequencing Technology

Qingqing Wang, Lili Qian, Shengwang Jiang, Chunbo Cai, Dezun Ma, Pengfei Gao, Hegang Li, Ke Jiang, Maoxue Tang, Jian Hou, Jie Liu, Wentao Cui

published 11 Mar 2016

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Changes in the miRNA-mRNA Regulatory Network Precede Motor Symptoms in a Mouse Model of Multiple System Atrophy: Clinical Implications

Simon Schafferer, Rimpi Khurana, Violetta Refolo, Serena Venezia, Edith Sturm, Paolo Piatti, Clara Hechenberger, Hubert Hackl, Roman Kessler, Michaela Willi, Ronald Gstir, Anne Krogsdam, Alexandra Lusser, Werner Poewe, Gregor K. Wenning, Alexander Hüttenhofer, Nadia Stefanova

published 10 Mar 2016

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IL-10 Production Is Critical for Sustaining the Expansion of CD5⁺ B and NKT Cells and Restraining Autoantibody Production in Congenic Lupus-Prone Mice

Yuriy Baglaenko, Kieran P. Manion, Nan-Hua Chang, Eric Gracey, Christina Loh, Joan E. Wither

published 10 Mar 2016

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A Variant of GJD2, Encoding for Connexin 36, Alters the Function of Insulin Producing β-Cells

Valentina Cigliola, Celine Populaire, Ciro L. Pierri, Samuel Deutsch, Jacques-Antoine Haefliger, João Fadista, Valeriya Lyssenko, Leif Groop, Rico Rueedi, Fabrizio Thorel, Pedro Luis Herrera, Paolo Meda

published 09 Mar 2016

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Hsp72 (HSPA1A) Prevents Human Islet Amyloid Polypeptide Aggregation and Toxicity: A New Approach for Type 2 Diabetes Treatment

Paola C. Rosas, Ganachari M. Nagaraja, Punit Kaur, Alexander Panossian, Georg Wickman, L. Rene Garcia, Fahd A. Al-Khamis, Alexzander A. A. Asea

published 09 Mar 2016

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Traditional Chinese Nootropic Medicine Radix Polygalae and Its Active Constituent Onjisaponin B Reduce β-Amyloid Production and Improve Cognitive Impairments

Xiaohang Li, Jin Cui, Yang Yu, Wei Li, Yujun Hou, Xin Wang, Dapeng Qin, Cun Zhao, Xinsheng Yao, Jian Zhao, Gang Pei

published 08 Mar 2016

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