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Genetically modified animals

Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis

Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney

published 10 Mar 2025

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Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells

Alyssa Kearly, Prontip Saelee, Jonathan Bard, Satrajit Sinha, Anne Satterthwaite, Lee Ann Garrett-Sinha

published 07 Mar 2025

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Expanding the fluorescent toolkit: Blue fluorescent protein-expressing Plasmodium berghei for enhanced multiplex microscopy

Kodzo Atchou, Reto Caldelari, Magali Roques, Jacqueline Schmuckli-Maurer, Raphael Beyeler, Volker Heussler

published 03 Mar 2025

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Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice

Naftali Horwitz, Michael Florea, K. C. Medha, Tina Liu, Vivian Garcia, Rebekah Kim, Amy Lam, Kathleen Messemer, Christopher Rios, Albert E. Almada, Amy J. Wagers

published 25 Feb 2025

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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo

Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J. Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

published 09 Jan 2025

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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B. Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E. Crawford, Stuart Bunting, Mika Aoyagi-Scharber

published 03 Jan 2025

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Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development

Rebecca K. Davidson, Kylie Corry, Amos Orlofsky, Ping Li, Caleb E. Russell, Amy Zhang, Mariana Moraes de Lima Perini, Carlie N. Priddy, Andrew V. Nguyen, Jiliang Li

published 17 Dec 2024

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Tumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production

Jiahao Zheng, Boran Li, Lanxin Jia, Jiayou Zhang, Zheng Gong, Yang Le, Xuanxuan Nian, Xuedan Li, Bo Liu, Daiguan Yu, Zhegang Zhang, Changgui Li

published 16 Dec 2024

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Peroxisomal dysfunction interferes with odontogenesis and leads to developmentally delayed teeth and defects in distinct dental cells in Pex11b-deficient mice

Claudia Colasante, Julia Jednakowski, Klaus-Peter Valerius, Xiaoling Li, Eveline Baumgart-Vogt

published 09 Dec 2024

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Mitochondrial fission is required for thermogenesis in brown adipose tissue

Yuta Ibayashi, Nao Hasuzawa, Seiji Nomura, Masaharu Kabashima, Ayako Nagayama, Shimpei Iwata, Miyuki Kitamura, Kenji Ashida, Yoshinori Moriyama, Ken Yamamoto, Masatoshi Nomura, Lixiang Wang

published 09 Dec 2024

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LARP7 is required for sex chromosome silencing during meiosis in mice

Yukiko Tando, Atsuto Nonomura, Yumi Ito-Matsuoka, Asuka Takehara, Daiji Okamura, Yohei Hayashi, Yasuhisa Matsui

published 05 Dec 2024

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TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5

Lijie Yang, Guanzheng Wang, Yuan Ma, Qiancheng Zhao, He Zhao, Qi Wang, Chonghua Zhong, Chunmei Zhang, Yiming Yang

published 05 Dec 2024

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Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice

Jacklyn R. Hurst, Maedeh Naghibosadat, Patrick Budowski, Jun Liu, Philip Samaan, Frans Budiman, Alexandra Kurtesi, Fredo Qi, Haritha Menon, Rajesh Krishnan, Jumai Abioye, Anne-Claude Gingras, Mario Ostrowski, Natalia Martin Orozco, Robert A. Kozak

published 03 Dec 2024

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