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Genetically modified animals

LARP7 is required for sex chromosome silencing during meiosis in mice

Yukiko Tando, Atsuto Nonomura, Yumi Ito-Matsuoka, Asuka Takehara, Daiji Okamura, Yohei Hayashi, Yasuhisa Matsui

published 05 Dec 2024

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TRPML1 acts as a predisposing factor in lymphedema development by regulating the subcellular localization of aquaporin-3, -5

Lijie Yang, Guanzheng Wang, Yuan Ma, Qiancheng Zhao, He Zhao, Qi Wang, Chonghua Zhong, Chunmei Zhang, Yiming Yang

published 05 Dec 2024

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Comparison of a SARS-CoV-2 mRNA booster immunization containing additional antigens to a spike-based mRNA vaccine against Omicron BA.5 infection in hACE2 mice

Jacklyn R. Hurst, Maedeh Naghibosadat, Patrick Budowski, Jun Liu, Philip Samaan, Frans Budiman, Alexandra Kurtesi, Fredo Qi, Haritha Menon, Rajesh Krishnan, Jumai Abioye, Anne-Claude Gingras, Mario Ostrowski, Natalia Martin Orozco, Robert A. Kozak

published 03 Dec 2024

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Single-cell sequencing reveals transcriptional dynamics regulated by ERα in mouse ovaries

Qicai Hu, Yiqian Gui, Congcong Cao, Jun Xie, Huiru Tang

published 21 Nov 2024

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Cardiac effects of OPA1 protein promotion in a transgenic animal model

Kitti Bruszt, Orsolya Horvath, Katalin Ordog, Szilard Toth, Kata Juhasz, Eszter Vamos, Katalin Fekete, Ferenc Gallyas, Kalman Toth, Robert Halmosi, Laszlo Deres

published 21 Nov 2024

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Evaluation of variation in preclinical electroencephalographic (EEG) spectral power across multiple laboratories and experiments: An EQIPD study

Tim P. Ahuis, Magdalena K. Smyk, Clément Laloux, Katharina Aulehner, Jack Bray, Ann-Marie Waldron, Nina Miljanovic, Isabel Seiffert, Dekun Song, Bruno Boulanger, Mathias Jucker, Heidrun Potschka, Bettina Platt, Gernot Riedel, Patrizia Voehringer, Janet R. Nicholson, Wilhelmus H. I. M. Drinkenburg, Martien J. H. Kas, Steven C. Leiser

published 29 Oct 2024

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The SWI/SNF subunit ARID1B is important for regenerative ability of hematopoietic stem cells in normal hematopoiesis

Olivia Arnold, Theresa Bluemn, Cary Stelloh, Sridhar Rao, Nan Zhu

published 24 Oct 2024

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Type 1 diabetes and parasite infection: An exploratory study in NOD mice

Emilie Giraud, Laurence Fiette, Evie Melanitou

published 22 Oct 2024

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Therapeutic potential of archaeal unfoldase PAN^et and the gateless T20S proteasome in P23H rhodopsin retinitis pigmentosa mice

Celine Brooks, Douglas Kolson, Emily Sechrest, Janelle Chuah, Jane Schupp, Neil Billington, Wen-Tao Deng, David Smith, Maxim Sokolov

published 03 Oct 2024

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Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model

Yuanqing Lu, Naweed S. Mohammad, Jungnam Lee, Alek M. Aranyos, Karina A. Serban, Mark L. Brantly

published 19 Sep 2024

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The aperiodic exponent of neural activity varies with vigilance state in mice and men

Freja Gam Østergaard, Brenda W. J. H. Penninx, Neetha Das, Celso Arango, Nic van der Wee, Inge Winter-van Rossum, Jose Luis Ayuso-Mateos, Gerard R. Dawson, Hugh Marston, Martien J. H. Kas

published 09 Aug 2024

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CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy

Honglin Wang, Eric Zi Rui Wang, Biao Feng, Subrata Chakrabarti

published 23 Jul 2024

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The expression of MIR125B transcripts and bone phenotypes in Mir125b2-deficient mice

Tomohiro Ogasawara, Shota Ito, Shintaro Ogashira, Tomonori Hoshino, Yusuke Sotomaru, Yuji Yoshiko, Kotaro Tanimoto

published 08 Jul 2024

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