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Genetically modified animals

Liver AMP-Activated Protein Kinase Is Unnecessary for Gluconeogenesis but Protects Energy State during Nutrient Deprivation

Clinton M. Hasenour, D. Emerson Ridley, Freyja D. James, Curtis C. Hughey, E. Patrick Donahue, Benoit Viollet, Marc Foretz, Jamey D. Young, David H. Wasserman

published 20 Jan 2017

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iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53

Harumasa Nakazawa, Kyungho Chang, Shohei Shinozaki, Takashi Yasukawa, Kazuhiro Ishimaru, Shingo Yasuhara, Yong-Ming Yu, J. A. Jeevendra Martyn, Ronald. G. Tompkins, Kentaro Shimokado, Masao Kaneki

published 18 Jan 2017

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Acute and Chronic Sustained Hypoxia Do Not Substantially Regulate Amyloid-β Peptide Generation In Vivo

Alberto Serrano-Pozo, Manuel A. Sánchez-García, Antonio Heras-Garvín, Rosana March-Díaz, Victoria Navarro, Marisa Vizuete, José López-Barneo, Javier Vitorica, Alberto Pascual

published 18 Jan 2017

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First Behavioural Characterisation of a Knockout Mouse Model for the Transforming Growth Factor (TGF)-β Superfamily Cytokine, MIC-1/GDF15

Jac Kee Low, Ananthan Ambikairajah, Kani Shang, David A. Brown, Vicky W. W. Tsai, Samuel N. Breit, Tim Karl

published 12 Jan 2017

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IL-37 Confers Protection against Mycobacterial Infection Involving Suppressing Inflammation and Modulating T Cell Activation

Haipeng Liu, Ruijuan Zheng, Peng Wang, Hua Yang, Xin He, Qun Ji, Wenjuan Bai, Hao Chen, Jianxia Chen, Wenxia Peng, Siyu Liu, Zhonghua Liu, Baoxue Ge

published 11 Jan 2017

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Growth-Enhanced Transgenic Coho Salmon (Oncorhynchus kisutch) Strains Have Varied Success in Simulated Streams: Implications for Risk Assessment

Rosalind A. Leggatt, L. Fredrik Sundström, Krista Woodward, Robert H. Devlin

published 09 Jan 2017

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Contribution of Vascular Cells to Neointimal Formation

Falei Yuan, Dong Wang, Kang Xu, Jixian Wang, Zhijun Zhang, Li Yang, Guo-Yuan Yang, Song Li

published 06 Jan 2017

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MITA/STING and Its Alternative Splicing Isoform MRP Restrict Hepatitis B Virus Replication

Shuhui Liu, Kaitao Zhao, Xi Su, Lu Lu, He Zhao, Xianwen Zhang, Yun Wang, Chunchen Wu, Jizheng Chen, Yuan Zhou, Xue Hu, Yanyi Wang, Mengji Lu, Xinwen Chen, Rongjuan Pei

published 05 Jan 2017

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Hepatocyte Hypoxia Inducible Factor-1 Mediates the Development of Liver Fibrosis in a Mouse Model of Nonalcoholic Fatty Liver Disease

Omar A. Mesarwi, Mi-Kyung Shin, Shannon Bevans-Fonti, Christina Schlesinger, Janet Shaw, Vsevolod Y. Polotsky

published 28 Dec 2016

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CD5-CK2 Signaling Modulates Erk Activation and Thymocyte Survival

Carlos A. Mier-Aguilar, Kevin S. Cashman, Chander Raman, Gloria Soldevila

published 28 Dec 2016

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The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissue-Specific Control of Metabolic Homeostasis

Rhianna C. Laker, Evan P. Taddeo, Yasir N. Akhtar, Mei Zhang, Kyle L. Hoehn, Zhen Yan

published 22 Dec 2016

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Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity

Blandine Poulet, Ke Liu, Darren Plumb, Phoung Vo, Mittal Shah, Katherine Staines, Alexandra Sampson, Hiroyuki Nakamura, Hideaki Nagase, Alessandra Carriero, Sandra Shefelbine, Andrew A. Pitsillides, George Bou-Gharios

published 21 Dec 2016

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Phospholamban Ablation Using CRISPR/Cas9 System Improves Mortality in a Murine Heart Failure Model

Manami Kaneko, Kentarou Hashikami, Satoshi Yamamoto, Hirokazu Matsumoto, Tomoyuki Nishimoto

published 16 Dec 2016

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