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Genetically modified animals

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, Mugdha Deshpande, Shin-ichi Matsumoto, Miyu Nakayama, Syunsuke Yamamoto, Bettina Strack-Logue, Takeshi Hioki, Maiko Tanaka, Gabriele Proetzel

published 07 May 2025

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Human cytomegalovirus-IE2 suppresses antigen presentation of macrophage through the IL10/STAT3 signalling pathway in transgenic mouse

Xianjuan Zhang, Qing Wang, Shuo Han, Guanghui Song, Bin Wang, Yunyang Wang

published 05 May 2025

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Adipocyte-specific deletion of Dbc1 does not recapitulate healthy obesity phenotype but suggests regulation of inflammation signaling

Leonardo Santos, Rafael Sebastián Fort, Geraldine Schlapp, Karina Cal, Valentina Perez-Torrado, Maria Noel Meikle, Ana Paula Mulet, Camila Espasandín, Camila Chiesa, José R. Sotelo-Silveira, Jose M. Verdes, Paola Contreras, Aldo J. Calliari, Martina Crispo, Jose L. Badano, Carlos Escande

published 02 May 2025

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Effect of pyrroloquinoline quinone on skin aging in Bmi-1 KO mice and underlying mechanisms

Bin Li, Xiao Meng Yang, Xiong Ming Zhou, Yuan Qing Huang

published 28 Mar 2025

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Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Hiroshi Tsuneki, Takahiro Maeda, Mayumi Takatsuki, Takahiro Sekine, Satsuki Masui, Kengo Onishi, Ryuta Takeda, Masanori Sugiyama, Takeshi Sakurai, Masashi Yanagisawa, Tsutomu Wada, Toshiyasu Sasaoka

published 26 Mar 2025

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Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4⁺ T cells during blood-stage Plasmodium infection

Takahiro Asatsuma, Marcela L. Moreira, Hyun J. Lee, Brooke J. Wanrooy, Oliver P. Skinner, Shihan Li, Ivana Rea, Taidhgin Harkin, Saba Asad, Cameron G. Williams, Lynette Beattie, Ashraful Haque

published 25 Mar 2025

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Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons

Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

published 18 Mar 2025

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Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis

Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney

published 10 Mar 2025

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Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells

Alyssa Kearly, Prontip Saelee, Jonathan Bard, Satrajit Sinha, Anne Satterthwaite, Lee Ann Garrett-Sinha

published 07 Mar 2025

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Expanding the fluorescent toolkit: Blue fluorescent protein-expressing Plasmodium berghei for enhanced multiplex microscopy

Kodzo Atchou, Reto Caldelari, Magali Roques, Jacqueline Schmuckli-Maurer, Raphael Beyeler, Volker Heussler

published 03 Mar 2025

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Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice

Naftali Horwitz, Michael Florea, K. C. Medha, Tina Liu, Vivian Garcia, Rebekah Kim, Amy Lam, Kathleen Messemer, Christopher Rios, Albert E. Almada, Amy J. Wagers

published 25 Feb 2025

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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo

Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J. Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

published 09 Jan 2025

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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B. Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E. Crawford, Stuart Bunting, Mika Aoyagi-Scharber

published 03 Jan 2025

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