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Genetically modified animals

Bromocriptine improves glucose tolerance in obese mice via central dopamine D2 receptor-independent mechanism

Hiroshi Tsuneki, Takahiro Maeda, Mayumi Takatsuki, Takahiro Sekine, Satsuki Masui, Kengo Onishi, Ryuta Takeda, Masanori Sugiyama, Takeshi Sakurai, Masashi Yanagisawa, Tsutomu Wada, Toshiyasu Sasaoka

published 26 Mar 2025

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Myosin 1f and Proline-rich 13 are transcriptionally upregulated yet functionally redundant in CD4⁺ T cells during blood-stage Plasmodium infection

Takahiro Asatsuma, Marcela L. Moreira, Hyun J. Lee, Brooke J. Wanrooy, Oliver P. Skinner, Shihan Li, Ivana Rea, Taidhgin Harkin, Saba Asad, Cameron G. Williams, Lynette Beattie, Ashraful Haque

published 25 Mar 2025

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Parthenolide regulates microglial and astrocyte function in primary cultures from ALS mice and has neuroprotective effects on primary motor neurons

Nadine Thau-Habermann, Thomas Gschwendtberger, Colin Bodemer, Susanne Petri

published 18 Mar 2025

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Podocyte specific knockout of the natriuretic peptide clearance receptor is podocyte protective in focal segmental glomerulosclerosis

Liming Wang, Yuping Tang, Anne F. Buckley, Robert F. Spurney

published 10 Mar 2025

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Sequences within and upstream of the mouse Ets1 gene drive high level expression in B cells, but are not sufficient for consistent expression in T cells

Alyssa Kearly, Prontip Saelee, Jonathan Bard, Satrajit Sinha, Anne Satterthwaite, Lee Ann Garrett-Sinha

published 07 Mar 2025

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Expanding the fluorescent toolkit: Blue fluorescent protein-expressing Plasmodium berghei for enhanced multiplex microscopy

Kodzo Atchou, Reto Caldelari, Magali Roques, Jacqueline Schmuckli-Maurer, Raphael Beyeler, Volker Heussler

published 03 Mar 2025

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Soluble RAGE enhances muscle regeneration after cryoinjury in aged and diseased mice

Naftali Horwitz, Michael Florea, K. C. Medha, Tina Liu, Vivian Garcia, Rebekah Kim, Amy Lam, Kathleen Messemer, Christopher Rios, Albert E. Almada, Amy J. Wagers

published 25 Feb 2025

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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo

Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J. Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

published 09 Jan 2025

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Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, Roger Lawrence, Kerui Gong, Hoonsan Ong, Bryan Yip, Joseph Chen, Linley Mangini, Britta Handyside, Alexander Giaramita, Aashish Lamichhane, Melanie Lo, Vishal Agrawal, Jeremy Van Vleet, Amanda Abolhesn, Jessica B. Felix, Isaac Villalpando, Vikas Bhat, Rolando De Angelis, Yuanbin Ru, Ayesha Khan, Sylvia Fong, Terri Christianson, Sherry Bullens, Brett E. Crawford, Stuart Bunting, Mika Aoyagi-Scharber

published 03 Jan 2025

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Loss of STAT3 in osteoblasts has detrimental and sexually dimorphic effects on skeletal development

Rebecca K. Davidson, Kylie Corry, Amos Orlofsky, Ping Li, Caleb E. Russell, Amy Zhang, Mariana Moraes de Lima Perini, Carlie N. Priddy, Andrew V. Nguyen, Jiliang Li

published 17 Dec 2024

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Tumorigenicity decrease in Bcl-xL deficient MDCK cells ensuring the safety for influenza vaccine production

Jiahao Zheng, Boran Li, Lanxin Jia, Jiayou Zhang, Zheng Gong, Yang Le, Xuanxuan Nian, Xuedan Li, Bo Liu, Daiguan Yu, Zhegang Zhang, Changgui Li

published 16 Dec 2024

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Peroxisomal dysfunction interferes with odontogenesis and leads to developmentally delayed teeth and defects in distinct dental cells in Pex11b-deficient mice

Claudia Colasante, Julia Jednakowski, Klaus-Peter Valerius, Xiaoling Li, Eveline Baumgart-Vogt

published 09 Dec 2024

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Mitochondrial fission is required for thermogenesis in brown adipose tissue

Yuta Ibayashi, Nao Hasuzawa, Seiji Nomura, Masaharu Kabashima, Ayako Nagayama, Shimpei Iwata, Miyuki Kitamura, Kenji Ashida, Yoshinori Moriyama, Ken Yamamoto, Masatoshi Nomura, Lixiang Wang

published 09 Dec 2024

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