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Genetically modified animals

Replacing murine insulin 1 with human insulin protects NOD mice from diabetes

Colleen M. Elso, Nicholas A. Scott, Lina Mariana, Emma I. Masterman, Andrew P. R. Sutherland, Helen E. Thomas, Stuart I. Mannering

published 10 Dec 2019

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Expressional artifact caused by a co-injection marker rol-6 in C. elegans

HoYong Jin, Scott W. Emmons, Byunghyuk Kim

published 04 Dec 2019

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Improved chemotherapy modeling with RAG-based immune deficient mice

Mark Wunderlich, Nicole Manning, Christina Sexton, Anthony Sabulski, Luke Byerly, Eric O’Brien, John P. Perentesis, Benjamin Mizukawa, James C. Mulloy

published 20 Nov 2019

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Beyond detoxification: Pleiotropic functions of multiple glutathione S-transferase isoforms protect mice against a toxic electrophile

Kelsey A. Behrens, Leigh A. Jania, John N. Snouwaert, MyTrang Nguyen, Sheryl S. Moy, Andrey P. Tikunov, Jeffrey M. Macdonald, Beverly H. Koller

published 20 Nov 2019

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Non-invasive in vivo imaging of UCP1 expression in live mice via near-infrared fluorescent protein iRFP720

Aya Fukuda, Shiho Honda, Norie Fujioka, Yuya Sekiguchi, Seiya Mizuno, Yoshihiro Miwa, Fumihiro Sugiyama, Yohei Hayashi, Ken Nishimura, Koji Hisatake

published 15 Nov 2019

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Autophagy deficiency exacerbates colitis through excessive oxidative stress and MAPK signaling pathway activation

Minori Kubota, Kazuki Kakimoto, Takatoshi Nakagawa, Eiko Koubayashi, Kei Nakazawa, Hideki Tawa, Yuki Hirata, Toshihiko Okada, Ken Kawakami, Akira Asai, Shuhei Hosomi, Toshihisa Takeuchi, Shinya Fukunishi, Takuya Inoue, Michio Asahi, Kazuhide Higuchi

published 08 Nov 2019

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APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy

Leslie A. Bruggeman, Zhenzhen Wu, Liping Luo, Sethu Madhavan, Paul E. Drawz, David B. Thomas, Laura Barisoni, John F. O'Toole, John R. Sedor

published 29 Oct 2019

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TEM8/ANTXR1-specific CAR T cells mediate toxicity in vivo

Kristina Petrovic, Joseph Robinson, Katharine Whitworth, Elizabeth Jinks, Abeer Shaaban, Steven P. Lee

published 17 Oct 2019

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Transgenic mouse model for conditional expression of influenza hemagglutinin-tagged human SLC20A1/PIT1

Sampada Chande, Bryan Ho, Jonathan Fetene, Clemens Bergwitz

published 15 Oct 2019

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An innovative non-invasive technique for subcutaneous tumour measurements

Juan Delgado-SanMartin, Beate Ehrhardt, Marcin Paczkowski, Sean Hackett, Andrew Smith, Wajahat Waraich, James Klatzow, Adeala Zabair, Anna Chabokdast, Leonardo Rubio-Navarro, Amar Rahi, Zena Wilson

published 14 Oct 2019

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A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression

Emilie A. Chapeau, Emeline Mandon, Jason Gill, Vincent Romanet, Nicolas Ebel, Violetta Powajbo, Rita Andraos-Rey, Zhiyan Qian, Miltos Kininis, Sabine Zumstein-Mecker, Moriko Ito, Nancy E. Hynes, Ralph Tiedt, Francesco Hofmann, Leonid Eshkind, Ernesto Bockamp, Bernd Kinzel, Matthias Mueller, Masato Murakami, Fabienne Baffert, Thomas Radimerski

published 10 Oct 2019

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Attenuation of renal fibrosis after unilateral ureteral obstruction in mice lacking the N-type calcium channel

Keiichiro Mishima, Masao Nakasatomi, Shunsuke Takahashi, Hidekazu Ikeuchi, Toru Sakairi, Yoriaki Kaneko, Keiju Hiromura, Yoshihisa Nojima, Akito Maeshima

published 09 Oct 2019

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Exposure to lipopolysaccharide (LPS) reduces contractile response of small airways from GSTCD^-/- mice

Bo Liu, Amanda P. Henry, Sheyda Azimi, Suzanne Miller, Frank K. Lee, Jane C. Lee, Kelly Probert, Michael I. Kotlikoff, Ian Sayers, Ian P. Hall

published 12 Sep 2019

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