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Genetically modified animals

Differential contribution of α2δ auxiliary subunits of voltage-gated calcium channels in mouse models of pain and itch

Joao M. Braz, Madison Jewell, Karnika Bhardwaj, Sian Rodriguez-Rosado, Veronica Craik, Allan I. Basbaum

published 02 Dec 2025

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Dysbiosis of gut microbiota in C57BL/6-Lep^em1hwl/Korl mice during microplastics-caused hepatic metabolism disruption

Yu Sang Choi, Yu Jeong Roh, Ji Eun Kim, Hee Jin Song, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ji Eun Sung, Ye Eun Ryu, Ye Ryeong Kim, Hyun Su Park, Hong Joo Son, Yu Jin Kim, Eun Sang Jung, Sunho Park, Dae Youn Hwang

published 20 Nov 2025

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UDP-glucuronic acid availability underlies sex difference in renal expression of nonsulfated Human Natural Killer-1 (HNK-1) glycans

Tomoko Onishi, Hajime Okayama, Hitomi Kitano, Katsuaki Higashi, Naoki Nakagawa, Motohiro Nonaka, Shogo Oka, Jyoji Morise

published 13 Nov 2025

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Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model

Meaghan Navarrete-Mathews, Gloria S. Lee, Angel Walerio, Dylan Horne, Yuying Wu, Yi Zhou

published 11 Nov 2025

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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Horacio Gomez-Acevedo, Ha-Neui Kim, Stavros C. Manolagas, Charles A. O’Brien, Elena Ambrogini

published 31 Oct 2025

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One IV HEDGES DNA vector administration encoding hGLA or hGH produces durable hGLA and hGH serum lvels in immunocompetent mice

Alice Ye, Marissa Mack, Sarah Ursu, Stephen Chmura, Robert Steiner, Tim Heath, Chakkrapong Handumrongkul, Robert Debs

published 31 Oct 2025

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Eliosin-an alternative product from the HmPKD1 locus is a component of endoplasmic reticulum mitochondria membrane contact sites

Almira Kurbegovic, Virginie Lazar, Wei-Min Xu, Maya Seshan, John S. Underwood, Radmila Micanovic, Jeremy M. Pomerantz, Rajneesh Srivastava, Sarath Janga, Emma H. Doud, Sherry Clendenon, Marie Trudel, Angela Wandinger-Ness, Robert L. Bacallao

published 30 Oct 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy

Huan Chang, Cancan Cheng, Ning Zheng, Haiyan Zhu, Hui Yang, Xiaocheng Zhu, Fan Zhang

published 09 Oct 2025

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Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells

Yuko Nakagawa, Takuro Horii, Ayako Fukunaka, Takashi Sato, Zhehao Zhang, Masaki Kobayashi, Tadahiro Kitamura, Yoshitaka Hayashi, Takashi Nishimura, Izuho Hatada, Yoshio Fujitani

published 23 Sep 2025

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Exploratory trajectory inference reveals convergent lineages for CD8 T cells in chronic LCMV infection

Jan T. Schleicher, Revant Gupta, Dario Cerletti, Ioana Sandu, Annette Oxenius, Manfred Claassen

published 19 Sep 2025

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ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon, Alia O. Alia, Jelena Popovic, Robert Vassar, Leah K. Cuddy

published 15 Sep 2025

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Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation

Ines Leila Paraiso, Armando Alcázar Magaña, Alexandra Alexiev, Thomas J. Sharpton, Claudia S. Maier, Chrissa Kioussi, Jan F. Stevens

published 05 Sep 2025

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