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Genetically modified animals

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Horacio Gomez-Acevedo, Ha-Neui Kim, Stavros C. Manolagas, Charles A. O’Brien, Elena Ambrogini

published 31 Oct 2025

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One IV HEDGES DNA vector administration encoding hGLA or hGH produces durable hGLA and hGH serum lvels in immunocompetent mice

Alice Ye, Marissa Mack, Sarah Ursu, Stephen Chmura, Robert Steiner, Tim Heath, Chakkrapong Handumrongkul, Robert Debs

published 31 Oct 2025

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Eliosin-an alternative product from the HmPKD1 locus is a component of endoplasmic reticulum mitochondria membrane contact sites

Almira Kurbegovic, Virginie Lazar, Wei-Min Xu, Maya Seshan, John S. Underwood, Radmila Micanovic, Jeremy M. Pomerantz, Rajneesh Srivastava, Sarath Janga, Emma H. Doud, Sherry Clendenon, Marie Trudel, Angela Wandinger-Ness, Robert L. Bacallao

published 30 Oct 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy

Huan Chang, Cancan Cheng, Ning Zheng, Haiyan Zhu, Hui Yang, Xiaocheng Zhu, Fan Zhang

published 09 Oct 2025

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Liver-specific glucagon dysfunction promotes PP-cell hyperplasia and formation of glucagon and PP double-positive cells

Yuko Nakagawa, Takuro Horii, Ayako Fukunaka, Takashi Sato, Zhehao Zhang, Masaki Kobayashi, Tadahiro Kitamura, Yoshitaka Hayashi, Takashi Nishimura, Izuho Hatada, Yoshio Fujitani

published 23 Sep 2025

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Exploratory trajectory inference reveals convergent lineages for CD8 T cells in chronic LCMV infection

Jan T. Schleicher, Revant Gupta, Dario Cerletti, Ioana Sandu, Annette Oxenius, Manfred Claassen

published 19 Sep 2025

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ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon, Alia O. Alia, Jelena Popovic, Robert Vassar, Leah K. Cuddy

published 15 Sep 2025

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Reversing metabolic dysregulation in farnesoid X receptor knockout mice via gut microbiota modulation

Ines Leila Paraiso, Armando Alcázar Magaña, Alexandra Alexiev, Thomas J. Sharpton, Claudia S. Maier, Chrissa Kioussi, Jan F. Stevens

published 05 Sep 2025

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Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome

Shunsuke Baba, Satoko Shinjo, Daiki Seya, Hiroki Bochimoto, Toru Akaike, Atsushi Nakano, Susumu Minamisawa

published 04 Sep 2025

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Do organisms need an impact factor? Citations of key biological resources including model organisms reveal usage patterns and impact

Agata Piekniewska, Martijn Roelandse, Kevin C. Kent Lloyd, Ian Korf, Stephen Randal Voss, Giovanni de Castro, Diogo M. Magnani, Zoltan Varga, Christina James-Zorn, Marko Horb, Jeffery S. Grethe, Anita Bandrowski

published 13 Aug 2025

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Partial FAM19A5 deficiency in mice leads to disrupted spine maturation, hyperactivity, and an altered fear response

Anu Shahapal, Sumi Park, Sangjin Yoo, Shi-Xun Ma, Jongha Lee, Hoyun Kwak, Jong-Ik Hwang, Jae Young Seong

published 05 Aug 2025

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Peripheral administration of blood from tau transgenic animals exacerbates brain tau-associated pathology

Laura Vegas-Gomez, Matias Pizarro, Jesus Garcia-Martin, Maria Angeles Arredondo-Alcala, Bianca Bustamante, Carolina Gonzalez-Silva, Soledad Matus, Rodrigo Diaz-Espinoza, Antonia Gutierrez, Rodrigo Morales, Claudia Duran-Aniotz, Ines Moreno-Gonzalez

published 15 Jul 2025

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