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Genetically modified animals

Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides

Motohiro Nonaka, Hideaki Mabashi-Asazuma, Donald L. Jarvis, Kazuhiko Yamasaki, Tomoya O. Akama, Masato Nagaoka, Toshio Sasai, Itsuko Kimura-Takagi, Yoichi Suwa, Takashi Yaegashi, Chun-Teng Huang, Chizuko Nishizawa-Harada, Michiko N. Fukuda

published 06 Jan 2021

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Ganoderma microsporum immunomodulatory protein, GMI, promotes C2C12 myoblast differentiation in vitro via upregulation of Tid1 and STAT3 acetylation

Wan-Huai Teo, Jeng-Fan Lo, Yu-Ning Fan, Chih-Yang Huang, Tung-Fu Huang

published 31 Dec 2020

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A longitudinal characterization of sex-specific somatosensory and spatial memory deficits in HIV Tg26 heterozygous mice

Mary F. Barbe, Regina Loomis, Adam M. Lepkowsky, Steven Forman, Huaqing Zhao, Jennifer Gordon

published 31 Dec 2020

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Reconfiguration of the cortical-hippocampal interaction may compensate for Sharp-Wave Ripple deficits in APP/PS1 mice and support spatial memory formation

Bartosz Jura, Dariusz Młoźniak, Hanna Goszczyńska, Katarzyna Blinowska, Nathalie Biendon, Nathalie Macrez, Pierre Meyrand, Tiaza Bem

published 31 Dec 2020

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In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia

Diogo Gonçalves, Guylène Rignol, Pierre Dellugat, Guido Hartmann, Stephanie Sarrazy Garcia, Jeffrey Stavenhagen, Luca Santarelli, Elvire Gouze, Christian Czech

published 28 Dec 2020

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Fluorescent indolizine derivative YI-13 detects amyloid-β monomers, dimers, and plaques in the brain of 5XFAD Alzheimer transgenic mouse model

DaWon Kim, Jeong Hwa Lee, Hye Yun Kim, Jisu Shin, Kyeonghwan Kim, Sejin Lee, Jinwoo Park, JinIkyon Kim, YoungSoo Kim

published 23 Dec 2020

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Genetic ablation of Cullin-RING E3 ubiquitin ligase 7 restrains pressure overload-induced myocardial fibrosis

Melanie Anger, Florian Scheufele, Deepak Ramanujam, Kathleen Meyer, Hidehiro Nakajima, Loren J. Field, Stefan Engelhardt, Antonio Sarikas

published 22 Dec 2020

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Noise-induced scaling in skull suture interdigitation

Yuto Naroda, Yoshie Endo, Kenji Yoshimura, Hiroshi Ishii, Shin-Ichiro Ei, Takashi Miura

published 17 Dec 2020

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Roles of Insulin Receptor Substrates (IRS) in renal function and renal hemodynamics

Seiji Hashimoto, Tomochika Maoka, Tetsuya Kawata, Toshio Mochizuki, Takao Koike, Takashi Shigematsu

published 03 Dec 2020

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Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells

Jun-ichi Kashiwakura, Kodai Saitoh, Takeru Ihara, Yuto Sasaki, Kota Kagohashi, Shiyo Enohara, Yuka Morioka, Hiroshi Watarai, Ryuta Muromoto, Yuichi Kitai, Kazuya Iwabuchi, Kenji Oritani, Tadashi Matsuda

published 11 Nov 2020

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UCHL1 regulates oxidative activity in skeletal muscle

Hongbo Gao, Ryan Antony, Rekha Srinivasan, Penglong Wu, Xuejun Wang, Yifan Li

published 02 Nov 2020

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Specific ablation of the NCoR corepressor δ splice variant reveals alternative RNA splicing as a key regulator of hepatic metabolism

Michael L. Goodson, Trina A. Knotts, Elsie L. Campbell, Chelsea A. Snyder, Briana M. Young, Martin L. Privalsky

published 26 Oct 2020

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Antigen-specific memory and naïve CD4⁺ T cells following secondary Chlamydia trachomatis infection

Jennifer D. Helble, Alexander O. Mann, Michael N. Starnbach

published 22 Oct 2020

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