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Genetically modified animals

Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Charles A. O’Brien, Horacio Gomez-Acevedo, Stavros C. Manolagas, Elena Ambrogini

published 29 Mar 2022

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Resistin production does not affect outcomes in a mouse model of acute surgical sepsis

Anthony S. Bonavia, Zissis C. Chroneos, Victor Ruiz-Velasco, Charles H. Lang

published 14 Mar 2022

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TNF-α induces Claudin-1 expression in renal tubules in Alport mice

Manami Iida, Shuichi Ohtomo, Naoko A. Wada, Otoya Ueda, Yoshinori Tsuboi, Atsuo Kurata, Kou-ichi Jishage, Naoshi Horiba

published 10 Mar 2022

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Cardiac specific knock-down of peroxisome proliferator activated receptor α prevents fasting-induced cardiac lipid accumulation and reduces perilipin 2

Natasha Fillmore, Vincent Hou, Junhui Sun, Danielle Springer, Elizabeth Murphy

published 08 Mar 2022

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Protocol for chronic hepatitis B virus infection mouse model development by patient-derived orthotopic xenografts

Aleksey M. Nagornykh, Marina A. Tyumentseva, Aleksandr I. Tyumentsev, Vasiliy G. Akimkin

published 23 Feb 2022

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Oxidant resistant human apolipoprotein A-I functions similarly to the unmodified human isoform in delaying atherosclerosis progression and promoting atherosclerosis regression in hyperlipidemic mice

Emmanuel Opoku, Stela Berisha, Gregory Brubaker, Peggy Robinet, Jonathan D. Smith

published 04 Feb 2022

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Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Chunxing Yang, Tao Qiao, Jia Yu, Hongyan Wang, Yansu Guo, Johnny Salameh, Jake Metterville, Sepideh Parsi, Issa Yusuf, Robert H. Brown, Huaibin Cai, Zuoshang Xu

published 03 Feb 2022

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Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis

Katherine R. Sadleir, Jelena Popovic, Ammaarah Khatri, Robert Vassar

published 02 Feb 2022

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Chronic spinal cord injury functionally repaired by direct implantation of encapsulated hair-follicle-associated pluripotent (HAP) stem cells in a mouse model: Potential for clinical regenerative medicine

Koya Obara, Kyoumi Shirai, Yuko Hamada, Nobuko Arakawa, Michiko Yamane, Nanako Takaoka, Ryoichi Aki, Robert M. Hoffman, Yasuyuki Amoh

published 27 Jan 2022

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Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice

Kristy L. Thomas, Callie L. Root, Jonathan M. Peterson

published 07 Jan 2022

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Beneficial impact of Ac3IV, an AVP analogue acting specifically at V1a and V1b receptors, on diabetes islet morphology and transdifferentiation of alpha- and beta-cells

Shruti Mohan, Ryan Lafferty, Neil Tanday, Peter R. Flatt, R. Charlotte Moffett, Nigel Irwin

published 20 Dec 2021

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Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting

Bernard Lassègue, Sandeep Kumar, Rohan Mandavilli, Keke Wang, Michelle Tsai, Dong-Won Kang, Catherine Demos, Marina S. Hernandes, Alejandra San Martín, W. Robert Taylor, Hanjoong Jo, Kathy K. Griendling

published 20 Dec 2021

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Tmprss6-ASO as a tool for the treatment of Polycythemia Vera mice

Carla Casu, Alison Liu, Gianluca De Rosa, Audrey Low, Aae Suzuki, Sayantani Sinha, Yelena Z. Ginzburg, Charles Abrams, Mariam Aghajan, Shuling Guo, Stefano Rivella

published 10 Dec 2021

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